DDX60L - DExD/H-box 60 like Gene

Homo sapiens

Gene ID: 91351 | Gene type: protein coding

About DDX60L

Cytogenetic location: 4q32.3 Genomic coordinates (GRCh38): 4:168,356,735-168,480,492 (from NCBI)

This gene has 16 transcripts (splice variants), 29 orthologues and 8 paralogues. Ubiquitous expression in appendix (RPKM 7.8), bone marrow (RPKM 6.5) and 24 other tissues.

Summary

This gene encodes a member of the DExD/H-box helicase family of proteins, a subset of the super family 2 helicases. Members of the DExD/H-box helicase family share a conserved functional core comprised of two RecA-like globular domains. These domains contain conserved motifs that mediate ATP binding, ATP hydrolysis, nucleic acid binding, and RNA unwinding. In addition to functions in RNA metabolism, members of this family are involved in anti-viral immunity and act as cytosolic sensors of viral nucleic acids. The protein encoded by this gene has been shown to inhibit hepatitis C virus replication in response to interferon stimulation in Cell Culture. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

DDX60L Products(7)

mRNA	Protein	Name
NM_001012967.3	NP_001012985.2	probable ATP-dependent RNA helicase DDX60-like isoform 1
NM_001291510.2	NP_001278439.1	probable ATP-dependent RNA helicase DDX60-like isoform 2
NM_001345927.2	NP_001332856.1	probable ATP-dependent RNA helicase DDX60-like isoform 3
NM_001378069.1	NP_001364998.1	probable ATP-dependent RNA helicase DDX60-like isoform 4
NM_001378070.1	NP_001364999.1	probable ATP-dependent RNA helicase DDX60-like isoform 4
NM_001378071.1	NP_001365000.1	probable ATP-dependent RNA helicase DDX60-like isoform 4
NM_001378072.1	NP_001365001.1	probable ATP-dependent RNA helicase DDX60-like isoform 3

DDX60L Protein Structure

DEAD

Helicase_C

0
300
600
900
1200
1500
1706 a.a.

Protein Preferred Names

Protein Names

probable ATP-dependent RNA helicase DDX60-like

DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like

Related Diseases

Diseases

Alias

Lip Cancer

Malignant Neoplasm Of Lip	Malignant Neoplasm Of Oral Aspect Of Lip, Not Specified Whether Upper Or Lower
Malignant Tumour Of Lip	Lip Neoplasms
Malignant Neoplasm Of Commissure Of Lip	Malignant Neoplasm Of External Lip, Not Specified As Upper Or Lower
Malignant Neoplasm Of Labial Commissure Of Lip	Malignant Neoplasm Of Lip, External
Malignant Neoplasm Of Lip, Inner Aspect	Malignant Neoplasm Of Lip, Vermilion Border
Malignant Neoplasm Of Lower Lip, Buccal Aspect	Malignant Neoplasm Of Lower Lip, Inner Aspect
Malignant Neoplasm Of Lower Lip, Mucosa	Malignant Neoplasm Of Lower Lip, Oral Aspect
Malignant Neoplasm Of Other Sites Of Lip	Malignant Neoplasm Of Vermilion Border Of Lip
Malignant Tumor Of Commissure Of Lip	Malignant Tumor Of Labial Mucosa
Malignant Tumor Of Lip	Malignant Tumor Of Lower Labial Mucosa
Malignant Tumor Of The Lip	Malignant Tumour Of Labial Commissure
Cancer Of Lip	Primary Malignant Neoplasm Of Vermilion Border Of Upper Lip
Upper Lip Cancer	Lower Lip Cancer
Primary Malignant Neoplasm Of Vermilion Border Of Lower Lip	Primary Malignant Neoplasm Of Vermilion Border Of Lip
Malignant Neoplasm Of Lipstick Area Of Upper Lip	Malignant Neoplasm Of Upper Lip Nos
Malignant Neoplasm Of Vermilion Border Of Upper Lip	Malignant Neoplasm Of Lipstick Area Of Lower Lip
Malignant Neoplasm Of Lower Lip Nos	Malignant Neoplasm Of Vermilion Border Of Lower Lip
Malignant Neoplasm Of Vermilion Border Nos	Malignant Neoplasm Of Buccal Aspect Of Upper Lip
Malignant Neoplasm Of Frenulum Of Upper Lip	Malignant Neoplasm Of Mucosa Of Upper Lip
Malignant Neoplasm Of Oral Aspect Of Upper Lip	Malignant Neoplasm Of Buccal Aspect Of Lower Lip
Malignant Neoplasm Of Frenulum Of Lower Lip	Malignant Neoplasm Of Mucosa Of Lower Lip
Malignant Neoplasm Of Oral Aspect Of Lower Lip	Malignant Neoplasm Of Buccal Aspect Of Lip, Not Specified Whether Upper Or Lower
Malignant Neoplasm Of Frenulum Of Lip, Not Specified Whether Upper Or Lower	Malignant Neoplasm Of Mucosa Of Lip, Not Specified Whether Upper Or Lower
Primary Malignant Neoplasm Of Commissure Of Lip	Primary Malignant Neoplasm Of Lip
Malignant Neoplasm Of Lip, Unspecified

Hepatitis C Virus

Hepatitis C Virus, Susceptibility To	Hepatitis C Virus Infection, Response To Therapy Of
Hcv	Hcv, Susceptibility To
Hepatitis C Virus, Resistance To	Hepatitis C Virus, Response To Therapy Of
Resistance To Hepatitis C Virus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03665	DDX60L Human Pre-designed siRNA Set A		/	Unkown

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