2. Gene
  3. SLC28A1 - solute carrier family 28 member 1 Gene

SLC28A1 - solute carrier family 28 member 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CNT1; HCNT1; URCTU

Gene ID: 9154 | Gene type: protein coding

About SLC28A1

Cytogenetic location: 15q25.3 Genomic coordinates (GRCh38): 15:84,884,662-84,975,649 (from NCBI)

This gene has 4 transcripts (splice variants), 198 orthologues, 2 paralogues and is associated with 1 phenotype. Biased expression in kidney (RPKM 9.5), small intestine (RPKM 9.4) and 2 other tissues.

Summary

Enables azole transmembrane transporter activity; cytidine transmembrane transporter activity; and uridine transmembrane transporter activity. Involved in azole transmembrane transport; nucleoside transport; and pyrimidine-containing compound transmembrane transport. Located in cytosol; nuclear speck; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SLC28A1 Products(6)

mRNA Protein Name
NM_001287761.2 NP_001274690.1 sodium/nucleoside cotransporter 1 isoform 3
NM_001287762.2 NP_001274691.1 sodium/nucleoside cotransporter 1 isoform 1
NM_001321721.2 NP_001308650.1 sodium/nucleoside cotransporter 1 isoform 4
NM_001321722.2 NP_001308651.1 sodium/nucleoside cotransporter 1 isoform 5
NM_004213.5 NP_004204.3 sodium/nucleoside cotransporter 1 isoform 1
NM_201651.3 NP_964014.1 sodium/nucleoside cotransporter 1 isoform 2

SLC28A1 Protein Structure

Nucleos_tra2_N

Nucleos_tra2_N: Na+ dependent nucleoside transporter N-terminus (184 - 255)

Gate

Gate: Nucleoside recognition (264 - 359)

Nucleos_tra2_C

Nucleos_tra2_C: Na+ dependent nucleoside transporter C-terminus (367 - 590)

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  • 649 a.a.
Protein Preferred Names Protein Names

sodium/nucleoside cotransporter 1

Na(+)/nucleoside cotransporter 1

Related Diseases

Diseases Alias
Uridine-Cytidineuria

URCTU
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13150 SLC28A1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SLC28A1 VGNC VGNC:34791
Rattus norvegicus SLC28A1 RGD RGD:621223
Felis catus SLC28A1 VGNC VGNC:65294
Mus musculus SLC28A1 MGD MGI:3605073
Macaca mulatta SLC28A1 VGNC VGNC:77444