SYT12 - synaptotagmin 12 Gene

Homo sapiens

Also known as SYT11; sytXII

Gene ID: 91683 | Gene type: protein coding

About SYT12

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:67,006,771-67,050,863 (from NCBI)

This gene has 7 transcripts (splice variants), 191 orthologues and 31 paralogues. Biased expression in brain (RPKM 5.6), liver (RPKM 2.3) and 5 other tissues.

Summary

This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. Studies of the orthologous gene in rat have shown that the encoded protein selectively modulates spontaneous synaptic-vesicle exocytosis and may also be involved in regulating calcium independent secretion in nonneuronal cells. Alternative splicing results in multiple transcript variants. The gene has previously been referred to as synaptotagmin XI but has been renamed synaptotagmin XII to be standard with mouse and rat official nomenclature.[provided by RefSeq, Apr 2010]

SYT12 Products(4)

mRNA	Protein	Name
NM_001177880.2	NP_001171351.1	synaptotagmin-12 isoform a
NM_001318773.2	NP_001305702.1	synaptotagmin-12 isoform b
NM_001318775.2	NP_001305704.1	synaptotagmin-12 isoform b
NM_177963.4	NP_808878.1	synaptotagmin-12 isoform a

SYT12 Protein Structure

0
100
200
300
421 a.a.

Protein Preferred Names

Protein Names

synaptotagmin-12

synaptotagmin-XII

Related Diseases

Diseases

Alias

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14109	SYT12 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SYT12	VGNC	VGNC:65894
Macaca mulatta	SYT12	VGNC	VGNC:78159
Mus musculus	SYT12	MGD	MGI:2159601
Canis familiaris	SYT12	VGNC	VGNC:47043
Bos taurus	SYT12	VGNC	VGNC:35538
Rattus norvegicus	SYT12	RGD	RGD:621876
Others	SYT12	NCBI

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