1. Gene
  2. MYOM2 - myomesin 2 Gene

MYOM2 - myomesin 2 Gene

Homo sapiens

Also known as TTNAP

Gene ID: 9172 | Gene type: protein coding

About MYOM2

Cytogenetic location: 8p23.3 Genomic coordinates (GRCh38): 8:2,045,046-2,145,456 (from NCBI)

This gene has 15 transcripts (splice variants), 1 gene allele, 279 orthologues and 11 paralogues. Biased expression in heart (RPKM 193.6) and prostate (RPKM 8.7).

Summary

The giant protein titin, together with its associated proteins, interconnects the major structure of sarcomeres, the M bands and Z discs. The C-terminal end of the titin string extends into the M line, where it binds tightly to M-band constituents of apparent molecular masses of 190 kD and 165 kD. The predicted MYOM2 protein contains 1,465 Amino acids. Like MYOM1, MYOM2 has a unique N-terminal domain followed by 12 repeat domains with strong homology to either fibronectin type III or immunoglobulin C2 domains. Protein sequence comparisons suggested that the MYOM2 protein and bovine M protein are identical. [provided by RefSeq, Jul 2008]

MYOM2 Products(1)

mRNA Protein Name
NM_003970.4 NP_003961.3 myomesin-2

MYOM2 Protein Structure

I-set

I-set: Immunoglobulin I-set domain (154 - 246)

I-set

I-set: Immunoglobulin I-set domain (289 - 372)

fn3

fn3: Fibronectin type III domain (385 - 469)

fn3

fn3: Fibronectin type III domain (513 - 597)

fn3

fn3: Fibronectin type III domain (613 - 695)

fn3

fn3: Fibronectin type III domain (713 - 797)

fn3

fn3: Fibronectin type III domain (817 - 899)

Ig_2

Ig_2: Immunoglobulin domain (1140 - 1209)

I-set

I-set: Immunoglobulin I-set domain (1351 - 1435)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1465 a.a.
Protein Preferred Names Protein Names

myomesin-2

165 kDa connectin-associated protein

Related Diseases

Diseases Alias
Rheumatic Fever

Acute Rheumatic Fever

Rhf - Rheumatic Fever

Inflammatory Rheumatism

Active Rheumatic Fever Nos

Acute Active Rheumatic Fever

Subacute Active Rheumatic Fever

Subacute Rheumatic Fever

Active Rheumatic Fever With Unspecified Type Of Heart Involvement

Acute Rheumatic Heart Disease

Active Rheumatic Heart Disease

Acute Organic Rhd - [Rheumatic Heart Disease]

Acute Rhd - [Rheumatic Heart Disease]

Blood Protein Disease

Blood Protein Disorders

Blood Protein Disorder

Monoclonal Gammopathy Of Uncertain Significance

Monoclonal Gammopathy Of Undetermined Significance

Mgus

Mgus - [Monoclonal Gammopathy Of Undetermined Significance]

Monoclonal Gammopathy Nos

Iga Gammopathy

Monoclonal Gammoglobulinopathy

Necrotizing Fasciitis

Fasciitis, Necrotizing

Poems Syndrome

Crow-Fukase Syndrome

Osteosclerotic Myeloma

Polyneuropathy Organomegaly

Polyneuropathy, Organomegaly, Endocrinopathy, M Protein, And Skin Changes Syndrome

Pep Syndrome

Polyneuropathy-Endocrinopathy-Plasma Cell Dyscrasia Syndrome

Takatsuki Syndrome

Toxic Shock Syndrome

Septic Shock

Toxic Shock

Tss

Shock, Septic

Staphylococcal Toxic Shock Syndrome

Tss - [Toxic Shock Syndrome]

Osteosclerotic Myeloma
Non-Secretory Myeloma
Solitary Osseous Plasmacytoma

Isolated Osseous Plasmacytoma

Solitary Plasmacytoma Of Bone

Smoldering Myeloma
Rheumatic Heart Disease

Rheumatic Carditis

Rheumatic Congestive Heart Failure

Congestive Rheumatic Heart Failure

Rheumatic Heart Failure

RHD

Rheumatic Fever Inactive Or Quiescent With Heart Disease

Rheumatic Fever Inactive Or Quiescent With Carditis

Organ Rheumatic Heart Disease

Organic Rheumatic Heart Disease

Inactive Rheumatic Heart Disease

Rheumatic Heart

Rheumatic Fever Inactive Or Quiescent With Pancarditis

Rhd - [Rheumatic Heart Disease]

Rheumatic Cardiac Hypertrophy

Rheumatic Fever

Inactive Or Quiescent With Cardiac Hypertrophy

Rheumatic Pancarditis

Inactive Rhd - [Rheumatic Heart Disease]

Rheumatic Nonischaemic Cardiopathy

Glomeruloid Hemangioma
Extramedullary Plasmacytoma

Extraosseous Plasmacytoma

Plasmacytoma, Extramedullary

Rheumatic Myocarditis

Acute Rheumatic Myocarditis

Active Rheumatic Fever With Myocarditis

Acute Rheumatic Carditis

Rheumatic Degeneration Of Myocardium

Rheumatic Fever With Myocarditis

Rheumatoid Myocarditis

Acute Rheumatic Heart Disease

Acute Rheumatic Fever With Myocarditis

Active Or Acute Rheumatic Myocarditis

Active Rheumatic Myocarditis

Active Rheumatic Progressive Myocarditis

Chronic Active Rheumatic Myocarditis

Old Active Rheumatic Myocarditis

Active Rheumatic Fibroid Myocarditis

Active Rheumatic Interstitial Myocarditis

Acute Or Subacute Rheumatic Myocardial Insufficiency

Acute Rheumatic Toxic Myocarditis

Inactive Or Quiescent Rheumatic Fever With Myocarditis

Inactive Rheumatic Myocarditis

Rheumatic Progressive Myocarditis

Rheumatic Fibroid Myocarditis

Rheumatic Interstitial Myocarditis

Myocardial Degeneration With Rheumatic Fever

Myocardial Insufficiency With Rheumatic Fever

Rheumatic Cardiomyopathy

Dilated Cardiomyopathy Due To Rheumatic Fever

Myocarditis Due To Rheumatic Fever

Rheumatic Myocardial Insufficiency

Subacute Sclerosing Panencephalitis

SSPE

Dawson Encephalitis

Immunosuppressive Measles Encephalitis

Subacute Sclerosing Leukoencephalitis

Panencephalitis, Subacute Sclerosing

Subacute Sclerosing Leukoencephalopathy

Van Bogaert'S Sclerosing Leukoencephalitis

Dawson Disease

Subacute Inclusion Body Encephalitis

Van Bogaert Disease

Van Bogaert Encephalitis

Measles Inclusion Body Encephalitis

Mibe - [Measles Inclusion Body Encephalitis]

Sspe - [Subacute Sclerosing Panencephalitis]

Van Bogaert Leukoencephalitis

Van Bogaert Sclerosing Leukoencephalitis

Dawson Inclusion Body Encephalitis

Van Bogaert Sclerosing Leukoencephalopathy

Bodechtel Guttman Disease

Diffuse Sclerosing Encephalitis

Scarlet Fever

Scarlatina

Scarlatina Nos

Spinal Polio
Bulbospinal Polio
Acute Poststreptococcal Glomerulonephritis

Post-Streptococcal Glomerulonephritis

Acute Post-Streptococcal Glomerulonephritis

Immunoglobulin Light Chain Amyloidosis

Al Amyloidosis

Primary Amyloidosis

Primary Systemic Amyloidosis

Light Chain Amyloidosis

Amyloidosis Al

Amyloidosis Primary Systemic

Primary Al Amyloidosis

Primary Systemic Al Amyloidosis

Systemic Al Amyloidsis

Systemic Al Amyloidosis

Light-Chain Amyloidosis

Alys Amyloidosis

Familial Amyloid Nephropathy Due To Lysozyme Variant

Familial Renal Amyloidosis Due To Lysozyme Variant

Hereditary Amyloid Nephropathy Due To Lysozyme Variant

Hereditary Renal Amyloidosis Due To Lysozyme Variant

Lysozyme Amyloidosis

Amyloidosis Primary

Immunoglobulin Deposition Disease

Immunoglobulinic Amyloidosis

Amyloid Al

Indolent Plasma Cell Myeloma

Indolent Myeloma

Indolent Multiple Myeloma

Impetigo
Lymphoplasmacytic Lymphoma

Waldenstrom Macroglobulinemia

Malignant Lymphoma - Lymphoplasmacytic

Waldenström Macroglobulinaemia

Waldenström Macroglobulinaemia Without Mention Of Remission

Idiopathic Macroglobulinaemia

Primary Macroglobulinaemia

Plasma Protein Metabolism Disease
Commensal Bacterial Infectious Disease
Acute Serous Otitis Media

Acute Non-Suppurative Otitis Media - Serous

Acute Transudative Otitis Media

Amyloidosis

Amyloid Disease

Amyloid

Amyloid Degeneration

Amyloidosis Nos

Amyloid Deposition

Amyloid Infiltration

Idiopathic Amyloidosis

Hyaloid Degeneration

Lardaceous Degeneration

Heavy Chain Disease

Hcd

Mature B-Cell Neoplasm

Mature B-Cell Lymphocytic Neoplasm

Neoplasm Of Mature B-Cells

Mature B-Cell Non-Hodgkin Neoplasm With Leukaemic Behaviour

Pharyngitis

Acute Pharyngitis

Chronic Pharyngitis

Acute Sore Throat

Chronic Sore Throat

Persistent Sore Throat

Pharyngeal Diseases

Chronic Pharyn/Nasopharyngitis

Chronic Pharyngitis And Nasopharyngitis

Inflamed Throat

Pharyngeal Disease

Pharyngeal Disorder

Pharyngitis - Acute

Sore Throat - Chronic

Acute Pharyngitis Nos

Acute Sore Throat Nos

Acute Throat Inflammation

Infective Pharyngitis

Infection Of Pharynx

Acute Infective Pharyngitis

Acute Infective Pharyngitis Nos

Acute Pharyngeal Inflammation

Inflammation Of The Throat

Throat Inflammation

Throat Infection

Putrid Pharyngitis

Pharyngeal Inflammation

Pharyngitis Nos

Chronic Throat Pain

Throat Catarrh

Papilledema

Choked Disk

Edema Of The Optic Disc

Demyelinating Polyneuropathy

Peripheral Demyelinating Neuropathy

Demyelinating Peripheral Neuropathy

Pulmonary Coin Lesion

Coin Lesion Of Lung

Solitary Pulmonary Nodule

Coin Lesion Lung

Pyoderma
Alpha Chain Disease

Seligmann'S Disease

Immunoproliferative Small Intestinal Disease

Plasma Cell Leukemia

Plasma Cell Leukaemia

Leukemia, Plasma Cell

Plasmacytic Leukaemia

Plasmacytic Leukemia

Pcl

Plasma Cell Leukaemia, Nos

Leukemic Plasma Cell

Plasma Cell Leukaemia Without Mention Of Remission

Pyomyositis

Tropical Pyomyositis

Myositis Tropicans

Myositis Purulenta Tropica

Pm

Suppurative Myositis

Purulent Myositis

Bone Marrow Cancer

Malignant Neoplasm Of Bone Marrow

Bone Marrow Neoplasm

Bone Marrow Tumor

Malignant Bone Marrow Tumor

Myeloproliferative Disorders

Bone Marrow Neoplasms

Myeloproliferative Disease

Chronic Myeloproliferative Disorder

Mononeuritis Of Upper Limb And Mononeuritis Multiplex
Cellulitis
Erysipelas
Chronic Inflammatory Demyelinating Polyradiculoneuropathy

Chronic Inflammatory Demyelinating Polyneuropathy

Cidp

Polyradiculoneuropathy Chronic Inflammatory Demyelinating

Polyradiculoneuropathy, Chronic Inflammatory Demyelinating

Tetralogy Of Fallot

TOF

Fallot Tetralogy

Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle

Tetrad Of Fallot

Fallot Tetrad

Fallot Disease

Fallot Complex

Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy

Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle

Interventricular Septal Defect, In Tetralogy Of Fallot

Ventricular Septal Defect With Obstructed Right Ventricular Outflow

Tof - [Tetralogy Of Fallot]

Pulmonary Atresia With Ventricular Septal Defect [Fallot Type]

Pulmonary Atresia, Ventricular Septal Defect And Mapcas

Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]

Waldenstroem'S Macroglobulinemia

Waldenstrom Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Waldenström Macroglobulinemia

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstrom'S Macroglobulinaemia

Waldenstrom'S Syndrome

Waldenstrom'S Macroglobulinemia

Wm

Waldenström'S Macroglobulinemia

Malignant Lymphoma - Lymphoplasmacytic

Mechanical Ectropion
Mineral Metabolism Disease

Mineral Metabolism Disorder

Disorder Of Mineral Metabolism

Retinitis Pigmentosa 46

RP46

Retinitis Pigmentosa, Autosomal Recessive, Idh3b-Related

Retinitis Pigmentosa Autosomal Recessive Idh3b-Related

Retinitis Pigmentosa, Type 46

Streptococcal Meningitis
Myeloma, Multiple

Multiple Myeloma

Plasma Cell Myeloma

Kahler Disease

Myelomatosis

Medullary Plasmacytoma

Multiple Myeloma, Resistance To

Myeloma

Plasma Cell Dyscrasia

Kahler'S Disease

Multiple Myeloma, Susceptibility To

Myeloma - Multiple

Kahler-Bozzolo Disease

Plasma Cell Myelomas

MM

Plasma Cell Neoplasm

Primary Systemic Amyloidosis

Primary Amyloidosis

Immunoglobulin Deposition Disease

Plasmacytic Myeloma

Multiple Myelomata

Multiple Myeloma Nos

Multiple Myeloma Without Mention Of Remission

Monostotic Plasma Cell Myeloma

Mm - [Multiple Myeloma]

Cardiomyopathy, Familial Hypertrophic, 6

Hypertrophic Cardiomyopathy 6

CMH6

Familial Hypertrophic Cardiomyopathy With Wolff-Parkinson-White Syndrome

Cardiomyopathy, Familial Hypertrophic 6

Cardiomyopathy, Hypertrophic 6

Cardiomyopathy, Hypertrophic, Familial, Type 6

Leukocyte Disease

Leukocyte Disorders

Proliferative Glomerulonephritis
Mixed Cerebral Palsy

Cerebral Palsy, Mixed

Multicentric Castleman Disease

Mcd

Multicentric Giant Lymph Node Hyperplasia

Plasmablastic Multicentric Castleman Disease

Pmcd

Idiopathic Multicentric Castleman Disease

Multi-Centric Castleman'S Disease

Idiopathic Multicentric Castleman'S Disease

Multicentric Plasma Cell Variant Of Castleman'S Disease

Hhv-8-Negative Multicentric Castleman Disease

Human Herpesvirus-8-Negative Multicentric Castleman Disease

Castleman Disease

Angiofollicular Ganglionic Hyperplasia

Angiofollicular Lymph Hyperplasia

Giant Lymph Node Hyperplasia

Castleman'S Disease

Angiofollicular Lymph Node Hyperplasia

Lymphoid Hamartoma

Benign Giant Lymphoma

Angiolymphoid Hyperplasia

Heart Disease

Heart Failure

Congenital Heart Disease

Heart Diseases

Congenital Heart Defects

Congenital Heart Defect

Heart Malformation

Congenital Anomaly Of Heart

Heart Defect

Heart-Congenital Defect

Congenital Heart Disorder

Heart Defects Congenital

Heart Defects, Congenital

Heart Defects

Heart Disease, Congenital

Disease, Heart, Congenital

Congestive Heart Failure

Septic Arthritis

Infectious Arthritis

Arthritis, Infectious

Arthritis Septic

Arthritis, Bacterial

Conjunctival Deposit
Plasma Cell Neoplasm

Plasma Cell Dyscrasia

Paraproteinemias

Plasma Cell Tumour

Plasmacytic Tumor

Multiple Myeloma

Plasmacytoma

Plasma Cell Tumours

Plasma Cells Dyscrasia

Heart Valve Disease

Heart Valve Diseases

Valvular Heart Disease

Valvular Heart Diseases

Heart Valve Prolapse

Polyneuropathy

Polyneuropathies

Myopathy, Lactic Acidosis, And Sideroblastic Anemia 3

MLASA3

Lethal Congenital Contracture Syndrome 4

LCCS4

Contracture Syndrome, Lethal, Congenital, Type 4

Peripheral Nervous System Disease

Peripheral Neuropathy

Peripheral Nerve Disease

Peripheral Nerve Disorders

Neuropathy, Peripheral

Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation

Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy

Cardiomyopathy, Hypertrophic

Cardiomyopathy Hypertrophic Obstructive

Cardiomyopathy, Hypertrophic, Familial

Idiopathic Myocardial Hypertrophy

Idiopathic Hypertrophic Cardiomyopathy

Obstructive Idiopathic Hypertrophic Cardiomyopathy

Obstructive Cardiomyopathy

Idiopathic Hypertrophic Subaortic Stenosis

Muscular Subaortic Stenosis

Hypertrophic Obstructive Subaortic Stenosis

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy

Primary Dilated Cardiomyopathy

Idiopathic Dilated Cardiomyopathy

Congestive Cardiomyopathy

Idiopathic Dilation Cardiomyopathy

Primary Familial Dilated Cardiomyopathy

Cardiomyopathy, Dilated

DCM

Cardiomyopathy, Familial Dilated

Dilated Cardiomyopathy, Familial

Hypokinetic Dilated Cardiomyopathy, Familial

Familial Idiopathic Cardiomyopathy

Fdc

Cardiomyopathy, Familial Idiopathic

Idiopathic Cardiomegaly

Dilated Congestive Cardiomyopathy

Chronic Dilated Cardiomyopathy

Ccm - [Congestive Cardiomyopathy]

Cocm - [Congestive Cardiomyopathy]

Dcm - [Dilated Cardiomyopathy]

Dilated-Hypokinetic Cardiomyopathy

Congestive Idiopathic Cardiomyopathy

Primary Idiopathic Dilated Cardiomyopathy

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Canis familiaris MYOM2 VGNC VGNC:105239
Mus musculus MYOM2 MGD MGI:1328358
Macaca mulatta MYOM2 VGNC VGNC:75124
Rattus norvegicus MYOM2 RGD RGD:631437
Bos taurus MYOM2 VGNC VGNC:31838
Felis catus MYOM2 VGNC VGNC:68406