2. Gene
  3. LRRFIP1 - LRR binding FLII interacting protein 1 Gene

LRRFIP1 - LRR binding FLII interacting protein 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GCF2; TRIP; FLAP1; GCF-2; FLAP-1; HUFI-1; FLIIAP1

Gene ID: 9208 | Gene type: protein coding

About LRRFIP1

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:237,627,587-237,781,643 (from NCBI)

This gene has 17 transcripts (splice variants), 293 orthologues and 1 paralogue. Ubiquitous expression in lung (RPKM 14.3), bone marrow (RPKM 12.6) and 25 other tissues.

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Involved in negative regulation of transcription by RNA polymerase II. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

LRRFIP1 Products(5)

mRNA Protein Name
NM_001137550.2 NP_001131022.1 leucine-rich repeat flightless-interacting protein 1 isoform 1
NM_001137551.2 NP_001131023.1 leucine-rich repeat flightless-interacting protein 1 isoform 2
NM_001137552.2 NP_001131024.1 leucine-rich repeat flightless-interacting protein 1 isoform 3
NM_001137553.2 NP_001131025.1 leucine-rich repeat flightless-interacting protein 1 isoform 5
NM_004735.4 NP_004726.2 leucine-rich repeat flightless-interacting protein 1 isoform 4

LRRFIP1 Protein Structure

LRRFIP

LRRFIP: LRRFIP family (23 - 316)

  • 0
  • 200
  • 400
  • 600
  • 808 a.a.
Protein Preferred Names Protein Names

leucine-rich repeat flightless-interacting protein 1

GC-binding factor 2

Related Diseases

Diseases Alias
Marasmus

Nutritional Marasmus

Nutritional Atrophy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07830 LRRFIP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris LRRFIP1 VGNC VGNC:59085
Macaca mulatta LRRFIP1 VGNC VGNC:99376
Mus musculus LRRFIP1 MGD MGI:1342770
Rattus norvegicus LRRFIP1 RGD RGD:1359548
Bos taurus LRRFIP1 VGNC VGNC:55253
Felis catus LRRFIP1 VGNC VGNC:107576
Others LRRFIP1 NCBI