GPR50 - G protein-coupled receptor 50 Gene

Homo sapiens

Also known as H9; Mel1c

Gene ID: 9248 | Gene type: protein coding

About GPR50

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:151,176,584-151,182,856 (from NCBI)

This gene has 1 transcript (splice variant), 181 orthologues and 33 paralogues. Low expression observed in reference dataset.

Summary

This gene product belongs to the G-protein coupled receptor 1 family. Even though this protein shares similarity with the melatonin receptors, it does not bind melatonin, however, it inhibits Melatonin Receptor 1A function through heterodimerization. Polymorphic variants of this gene have been associated with bipolar affective disorder in women. [provided by RefSeq, Jan 2010]

GPR50 Products(1)

mRNA	Protein	Name
NM_004224.3	NP_004215.2	melatonin-related receptor

GPR50 Protein Structure

7tm_1

0
100
200
300
400
500
617 a.a.

Protein Preferred Names

Protein Names

melatonin-related receptor

Related Diseases

Diseases

Alias

Pituitary Adenoma 2, Growth Hormone-Secreting

PITA2	Acromegaly Due To Pituitary Adenoma 2
Acromegaly, X-Linked	Growth Hormone Secreting Pituitary Adenoma 2
Pituitary Adenoma, Growth Hormone-Secreting, 2	Pituitary Adenoma 2, Gh-Secreting
Gh-Secreting Pituitary Adenoma 2	X-Linked Acromegaly
Adenoma, Pituitary, Growth Hormone-Secreting, Type 2

X-Linked Intellectual Disability-Psychosis-Macroorchidism Syndrome

Mrxs13	Lindsay-Burn Syndrome
Ppm-X	Ppm-X Syndrome
Mental Retardation With Psychosis, Pyramidal Signs, And Macroorchidism	Mental Retardation, X-Linked, Syndromic 13
X-Linked Mental Retardation 79	X-Linked Mental Retardation With Spasticity
Intellectual Deficit, X-Linked - Psychosis - Macroorchidism	Intellectual Disability Psychosis Macroorchidism
Intellectual Disability With Psychosis, Pyramidal Signs, And Macroorchidism	Intellectual Disability, X-Linked, Syndromic 13
Ppmx	X-Linked Mental Retardation, Syndromic 13

Delayed Sleep Phase Disorder

Delayed Sleep Phase Syndrome	Delayed Sleep Phase Syndrome, Susceptibility To
DSPD	Delayed Sleep Phase Disorder, Susceptibility To
DSPS	Sleep Phase, Delayed, Disorder
Sleep Phase Syndrome, Delayed, Susceptibility To

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Scoliosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05717	GPR50 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GPR50	MGD	MGI:1333877
Macaca mulatta	GPR50	VGNC	VGNC:73138
Canis familiaris	GPR50	VGNC	VGNC:41437
Rattus norvegicus	GPR50	RGD	RGD:619863
Bos taurus	GPR50	VGNC	VGNC:29589

Name
Email *

	Sorry, but the email address you supplied was invalid.