2. Gene
  3. CYTH3 - cytohesin 3 Gene

CYTH3 - cytohesin 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GRP1; ARNO3; PSCD3; cytohesin-3

Gene ID: 9265 | Gene type: protein coding

About CYTH3

Cytogenetic location: 7p22.1 Genomic coordinates (GRCh38): 7:6,161,779-6,272,624 (from NCBI)

This gene has 11 transcripts (splice variants), 293 orthologues and 15 paralogues. Ubiquitous expression in placenta (RPKM 22.7), fat (RPKM 21.0) and 23 other tissues.

Summary

This gene encodes a member of the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. PSCD family members have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with Phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This encoded protein is involved in the control of Golgi structure and function, and it may have a physiological role in regulating ADP-ribosylation factor protein 6 (ARF) functions, in addition to acting on ARF1. [provided by RefSeq, Jul 2008]

CYTH3 Products(4)

mRNA Protein Name
NM_001367580.1 NP_001354509.1 cytohesin-3 isoform b
NM_001367581.1 NP_001354510.1 cytohesin-3 isoform c
NM_001367582.1 NP_001354511.1 cytohesin-3 isoform c
NM_004227.4 NP_004218.1 cytohesin-3 isoform a

CYTH3 Protein Structure

Sec7

Sec7: Sec7 domain (66 - 163)

PH

PH: PH domain (182 - 295)

  • 0
  • 100
  • 200
  • 314 a.a.
Protein Preferred Names Protein Names

cytohesin-3

ARF nucleotide-binding site opener 3

Related Diseases

Diseases Alias
Corneal Dystrophy, Posterior Amorphous

Posterior Amorphous Corneal Dystrophy

PACD

Chromosome 12q21.33 Deletion Syndrome

Posterior Amorphous Stromal Dystrophy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03502 CYTH3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CYTH3 VGNC VGNC:69096
Mus musculus CYTH3 MGD MGI:1335107
Rattus norvegicus CYTH3 RGD RGD:620399
Macaca mulatta CYTH3 VGNC VGNC:71829
Bos taurus CYTH3 VGNC VGNC:58371
Canis familiaris CYTH3 VGNC VGNC:49080