GPR37L1 - G protein-coupled receptor 37 like 1 Gene

Homo sapiens

Also known as ETBRLP2; ETBR-LP-2; ET(B)R-LP-2

Gene ID: 9283 | Gene type: protein coding

About GPR37L1

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:202,122,917-202,133,592 (from NCBI)

This gene has 7 transcripts (splice variants), 264 orthologues and 15 paralogues. Biased expression in brain (RPKM 18.1) and colon (RPKM 0.5).

Summary

Enables G protein-coupled peptide receptor activity; peptide binding activity; and prosaposin receptor activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway and positive regulation of MAPK cascade. Located in plasma membrane. Part of receptor complex. [provided by Alliance of Genome Resources, Apr 2022]

GPR37L1 Products(1)

mRNA	Protein	Name
NM_004767.5	NP_004758.3	G-protein coupled receptor 37-like 1 precursor

GPR37L1 Protein Structure

7tm_1

0
100
200
300
400
481 a.a.

Protein Preferred Names

Protein Names

G-protein coupled receptor 37-like 1

endothelin B receptor-like protein 2

Related Diseases

Diseases

Alias

Epilepsy, Familial Temporal Lobe, 6

ETL6	Familial Temporal Lobe Epilepsy 6

Megalencephalic Leukoencephalopathy With Subcortical Cysts

Vacuolating Megalencephalic Leukoencephalopathy With Subcortical Cysts	Mlc
Van Der Knaap Disease	Lvm
Leukoencephalopathy With Swelling And Cysts	Megalencephaly-Cystic Leukodystrophy
Megalencephalic Leukodystrophy Megalencephaly-Cystic Leukodystorphy Syndrome	Infantile Leukoencephalopathy And Megalencephaly
Leukoencephalopathy With Swelling And A Discrepantly Mild Course	Vacuolating Leukoencephalopathy
Megalencephalic Leukodystrophy	Megalencephaly-Cystic Leukodystrophy Syndrome
Van Der Knaap Syndrome	Leukoencephalopathy, Megalencephalic, With Subcortical Cysts

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05710	GPR37L1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GPR37L1	VGNC	VGNC:62691
Canis familiaris	GPR37L1	VGNC	VGNC:41433
Macaca mulatta	GPR37L1	VGNC	VGNC:72943
Mus musculus	GPR37L1	MGD	MGI:1928503
Bos taurus	GPR37L1	VGNC	VGNC:29586
Rattus norvegicus	GPR37L1	RGD	RGD:628835

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