2. Gene
  3. NRXN2 - neurexin 2 Gene

NRXN2 - neurexin 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 9379 | Gene type: protein coding

About NRXN2

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:64,606,174-64,723,197 (from NCBI)

This gene has 20 transcripts (splice variants), 291 orthologues, 35 paralogues and is associated with 1 phenotype. Biased expression in brain (RPKM 25.4), testis (RPKM 3.9) and 2 other tissues.

Summary

This gene encodes a member of the neurexin gene family. The products of these genes function as cell adhesion molecules and receptors in the vertebrate nervous system. These genes utilize two promoters. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms while a smaller number of transcripts are produced from the downstream promoter and encode beta-neuresin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. Alternative splicing and the use of alternative promoters may generate thousands of transcript variants (PMID: 12036300, PMID: 11944992).[provided by RefSeq, Jun 2010]

NRXN2 Products(10)

mRNA Protein Name
NM_001376262.1 NP_001363191.1 neurexin-2-beta isoform 4 precursor
NM_001376263.1 NP_001363192.1 neurexin-2-beta isoform 5 precursor
NM_001376265.1 NP_001363194.1 neurexin-2-beta isoform 7 precursor
NM_001376266.1 NP_001363195.1 neurexin-2-beta isoform 6 precursor
NM_001376267.1 NP_001363196.1 neurexin-2-beta isoform 8 precursor
NM_001400681.1 NP_001387610.1 neurexin-2-beta isoform 9
NM_001400682.1 NP_001387611.1 neurexin-2-beta isoform 10
NM_015080.4 NP_055895.1 neurexin-2-beta isoform alpha-1 precursor
NM_138732.3 NP_620060.1 neurexin-2-beta isoform alpha-2 precursor
NM_138734.3 NP_620063.1 neurexin-2-beta isoform beta precursor

NRXN2 Protein Structure

Laminin_G_2

Laminin_G_2: Laminin G domain (57 - 186)

Laminin_G_2

Laminin_G_2: Laminin G domain (318 - 458)

Laminin_G_2

Laminin_G_2: Laminin G domain (521 - 666)

Laminin_G_2

Laminin_G_2: Laminin G domain (760 - 890)

Laminin_G_2

Laminin_G_2: Laminin G domain (946 - 1074)

Laminin_G_2

Laminin_G_2: Laminin G domain (1169 - 1317)

Syndecan

Syndecan: Syndecan domain (1636 - 1674)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1712 a.a.
Protein Preferred Names Protein Names

neurexin-2-beta

neurexin II

Recombinant NRXN2 Proteins

Cat. No. Product Name Accession Purity
HY-P79237 NRXN2/Neurexin 2 alpha Isoform 2 Protein, Human (CHO, hFc) NP_620060 (M1 - T1566) ≥95%

Related Diseases

Diseases Alias
Pitt-Hopkins-Like Syndrome 2

PTHSL2

Mesh

D006985

Mesh

D008607
Pitt-Hopkins-Like Syndrome 1

Cortical Dysplasia-Focal Epilepsy Syndrome

CDFES

PTHSL1

Cdfe Syndrome

Pitt-Hopkins Like Syndrome 1

Pitt-Hopkins-Like Syndrome-1

Cntnap2-Related Developmental And Epileptic Encephalopathy

Cntnap2-Related Dee

Mesh

D006985

Mesh

D008607
Childhood Disintegrative Disease

Childhood Disintegrative Disorder

Disintegrative Psychosis

Heller'S Syndrome

Symbiotic Psychosis

Dementia Infantilis

Heller Syndrome

Shared Paranoid Disorder
Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified
Tic Disorder

Tics

Behavioral Tic
Syndromic X-Linked Intellectual Disability Najm Type

Mental Retardation And Microcephaly With Pontine And Cerebellar Hypoplasia

Micpch

X-Linked Intellectual Disability-Microcephaly-Pontocerebellar Hypoplasia Syndrome
Pervasive Developmental Disorder

Pervasive Development Disorder

Pervasive Developmental Disorders

Pervasive Child Development Disorders

Autistic Behavior

Autism Spectrum Disorders
Phelan-Mcdermid Syndrome

Chromosome 22q13.3 Deletion Syndrome

22q13.3 Deletion Syndrome

Telomeric 22q13 Monosomy Syndrome

PHMDS

Deletion 22q13 Syndrome

22q13.3 Deletion

Deletion 22q13.3 Syndrome

Monosomy 22q13

Monosomy 22q13.3

22q13 Deletion Syndrome

Monosomy 22q13 Syndrome

22q13 Deletion

Chromosome Deletion
Gilles De La Tourette Syndrome

Tourette Syndrome

Tourette Disorder

GTS

Ts

Gilles De La Tourette'S Syndrome

Motor-Verbal Tic Disorder

Guinon'S Disease

Psychogenic Tics

Tourette'S Syndrome

Chronic Motor And Vocal Tic Disorder

Td

Tourette'S Disease

Combined Vocal And Multiple Motor Tic Disorder [De La Tourette]

Combined Vocal And Multiple Motor Tic Disorder

Tic De La Tourette
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
Pitt-Hopkins Syndrome

PTHS

Encephalopathy, Severe Epileptic, With Autonomic Dysfunction

Mental Retardation, Syndromal, With Intermittent Hyperventilation

Intellectual Disability, Wide Mouth, Distinctive Facial Features, And Intermittent Hyperventilation Followed By Apnea

Pitt Hopkins Syndrome

Phs

Encephalopathy Severe Epileptic With Autonomic Dysfunction
Specific Developmental Disorder
Psychotic Disorder

Psychotic Disorders

Mental Or Behavioural Disorder

Psychotic

Mental Disorders
Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder

ADHD

Attention Deficit Disorder

Attention Deficit-Hyperactivity Disorder, Susceptibility To

Attention Deficit Disorder With Hyperactivity

Hyperkinetic Disorder

Hyperactivity Of Childhood

Attention-Deficit/Hyperactivity Disorder

Add

Addh

Attention Deficit

Attention Deficit Disorder Of Childhood With Hyperactivity

Attention Deficit Disorder With Hyperactivity Syndrome

Hyperkinetic Syndrome

Attention-Deficit Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

Disturbance Of Activity And Attention

Disorder Of Activity And Attention

Adhd - [Attention Deficit Hyperactivity Disorder]

Hyperkinetic Disorders

Disorder Of Activity And Attention With Hyperkinesia

Attention Deficit Syndrome With Hyperactivity
Syndromic Intellectual Disability
West Syndrome

Infantile Spasms

Infantile Spasms Syndrome

Infantile Spasm

X-Linked Infantile Spasm Syndrome

X-Linked Infantile Spasms

Epileptic Encephalopathy, Early Infantile, 1

Is

Tonic Spasms With Clustering, Arrest Of Psychomotor Development And Hypsarrhythmia On Eeg

West'S Syndrome

Spasms, Infantile

Is -[Infantile Spasm]

Salaam Spasm

Salaam Tic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09584 NRXN2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NRXN2 VGNC VGNC:32271
Felis catus NRXN2 VGNC VGNC:104316
Canis familiaris NRXN2 VGNC VGNC:43979
Rattus norvegicus NRXN2 RGD RGD:620211
Macaca mulatta NRXN2 VGNC VGNC:75534
Mus musculus NRXN2 MGD MGI:1096362