GGPS1 - geranylgeranyl diphosphate synthase 1 Gene

Homo sapiens

Also known as GGPPS; MDHLO; GGPPS1; MUDHLOV

Gene ID: 9453 | Gene type: protein coding

About GGPS1

Cytogenetic location: 1q42.3 Genomic coordinates (GRCh38): 1:235,327,216-235,344,532 (from NCBI)

This gene has 8 transcripts (splice variants), 203 orthologues, 2 paralogues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 14.2), prostate (RPKM 11.1) and 25 other tissues.

Summary

This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The Enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, both protein-coding and non-protein-coding, have been found for this gene. [provided by RefSeq, Sep 2010]

GGPS1 Products(5)

mRNA	Protein	Name
NM_001037277.1	NP_001032354.1	geranylgeranyl pyrophosphate synthase isoform A
NM_001037278.2	NP_001032355.1	geranylgeranyl pyrophosphate synthase isoform B
NM_001371477.1	NP_001358406.1	geranylgeranyl pyrophosphate synthase isoform A
NM_001371478.1	NP_001358407.1	geranylgeranyl pyrophosphate synthase isoform A
NM_004837.4	NP_004828.1	geranylgeranyl pyrophosphate synthase isoform A

GGPS1 Protein Structure

polyprenyl_synt

0
100
200
300 a.a.

Protein Preferred Names

Protein Names

geranylgeranyl pyrophosphate synthase

(2E,6E)-farnesyl diphosphate synthase

Recombinant GGPS1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70224	GGPS1 Protein, Human (His)	O95749 (M1-E300)	≥95%

Related Diseases

Diseases

Alias

Muscular Dystrophy, Congenital Hearing Loss, And Ovarian Insufficiency Syndrome

MDHLO

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Myasthenic Syndrome, Congenital, 2c, Associated With Acetylcholine Receptor Deficiency

Congenital Myasthenic Syndrome 2c	CMS2C
Congenital Myasthenic Syndrome 2c Associated With Acetylcholine Receptor Deficiency	Myasthenic Syndrome, Congenital, Type 2c, Associated With Acetylcholine Receptor Deficiency

Muscular Dystrophy

Muscular Dystrophies	Congenital Md
Congenital Muscular Dystrophy	Cmd
Mdc	Dystrophy, Muscular
Gower'S Muscular Dystrophy	Progressive Musclular Dystrophy
Pseudohypertrophic Atrophy	Pseudohypertrophic Muscle Paralysis
Pseudohypertrophic Muscular Atrophy	Pseudohypertrophic Muscular Dystrophy
Pseudohypertrophic Paralysis	Pseudomuscular Hypertrophy

Hyperinsulinism

Hyperinsulinemia

Mammary Paget'S Disease

Paget'S Disease	Mammary Paget Disease
Paget'S Disease Of The Breast	Paget Disease Of The Breast
Paget'S Disease Of The Nipple	Paget'S Disease, Mammary
Paget Cell Neoplasm	Paget Disease Of The Nipple
Pagets Disease Mammary	Osteitis Deformans

Porokeratosis

Disseminated Superficial Actinic Porokeratosis	Dsap
Porokeratosis Of Mibelli	Porokeratosis, Disseminated Superficial Actinic
Porokeratosis, Disseminated Superficial Actinic, 1

Sensorineural Hearing Loss

Sensory Hearing Loss	Sensorineural Deafness
Sensorineural Hearing Loss Disorder	Hearing Loss, Sensorineural
Central Hearing Loss	High Frequency Deafness
High Frequency Hearing Loss	High-Frequency Hearing Loss
Perceptive Deafness	Perceptive Hearing Loss
Perceptive Hearing Loss Or Deafness	Hearing Loss Sensorineural
Deafness Sensorineural	Hearing Loss High-Frequency
Hearing Loss, Central	Hearing Loss, High-Frequency

Perrault Syndrome

Gonadal Dysgenesis, Xx Type, With Deafness	Ovarian Dysgenesis With Sensorineural Deafness
Gonadal Dysgenesis, Xx Type	Gonadal Dysgenesis With Auditory Dysfunction, Autosomal Recessive Inheritance
Gonadal Dysgenesis With Sensorineural Deafness, Autosomal Recessive Inheritance	Xx Gonodal Dysgenesis-Deafness Syndrome
Xx Gonodal Dysgenesis-Hearing Loss Syndrome	Gonadal Dysgenesis Xx Type Deafness

Breast Adenocarcinoma

Mammary Adenocarcinoma

Adenocarcinoma Of Breast

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05402	GGPS1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	GGPS1	VGNC	VGNC:99960
Canis familiaris	GGPS1	VGNC	VGNC:41201
Felis catus	GGPS1	VGNC	VGNC:62539
Rattus norvegicus	GGPS1	RGD	RGD:1359680
Mus musculus	GGPS1	MGD	MGI:1341724
Bos taurus	GGPS1	VGNC	VGNC:29343
Others	GGPS1	NCBI

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