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  3. AKAP7 - A-kinase anchoring protein 7 Gene

AKAP7 - A-kinase anchoring protein 7 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as AKAP15; AKAP18

Gene ID: 9465 | Gene type: protein coding

About AKAP7

Cytogenetic location: 6q23.2 Genomic coordinates (GRCh38): 6:131,125,627-131,283,532 (from NCBI)

This gene has 10 transcripts (splice variants), 192 orthologues and 1 paralogue. Broad expression in adrenal (RPKM 12.1), duodenum (RPKM 4.2) and 23 other tissues.

Summary

This gene encodes a member of the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the Enzyme to specific subcellular compartments. AKAPs have a common RII-binding domain, but contain different targeting motifs responsible for directing PKA to distinct intracellular locations. Three alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Apr 2011]

AKAP7 Products(9)

mRNA Protein Name
NM_001376570.1 NP_001363499.1 A-kinase anchoring protein 7 isoform 4
NM_001387860.1 NP_001374789.1 A-kinase anchoring protein 7 isoform 5
NM_001387861.1 NP_001374790.1 A-kinase anchoring protein 7 isoform 6
NM_001387862.1 NP_001374791.1 A-kinase anchoring protein 7 isoform 7
NM_001387863.1 NP_001374792.1 A-kinase anchoring protein 7 isoform 8
NM_001387864.1 NP_001374793.1 A-kinase anchoring protein 7 isoform 9
NM_004842.4 NP_004833.1 A-kinase anchoring protein 7 isoform alpha
NM_016377.4 NP_057461.2 A-kinase anchoring protein 7 isoform gamma
NM_138633.3 NP_619539.1 A-kinase anchoring protein 7 isoform beta

AKAP7 Protein Structure

AKAP7_NLS

AKAP7_NLS: AKAP7 2'5' RNA ligase-like domain (85 - 281)

AKAP7_RIRII_bdg

AKAP7_RIRII_bdg: PKA-RI-RII subunit binding domain of A-kinase anchor protein (289 - 348)

  • 0
  • 100
  • 200
  • 300
  • 348 a.a.
Protein Preferred Names Protein Names

A-kinase anchoring protein 7

A kinase (PRKA) anchor protein 7

Related Diseases

Diseases Alias
Familial Febrile Seizures

Familial Febrile Convulsions

Feb

Febrile Seizures, Familial
Long Qt Syndrome 1

Romano-Ward Syndrome

LQT1

Ward-Romano Syndrome

Rws

Ventricular Fibrillation With Prolonged Qt Interval

Wrs

Long Qt Syndrome 1, Acquired, Susceptibility To

Long Qt Syndrome 1, Acquired

Romano-Ward Long Qt Syndrome

Long Qt Syndrome Type 1

Long Qt Syndrome-1

Acquired Susceptibility To Long Qt Syndrome 1

Qt Syndrome, Long, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00522 AKAP7 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus AKAP7 RGD RGD:1303071
Canis familiaris AKAP7 VGNC VGNC:37760
Bos taurus AKAP7 VGNC VGNC:25788
Macaca mulatta AKAP7 VGNC VGNC:69772
Mus musculus AKAP7 MGD MGI:1859150
Felis catus AKAP7 VGNC VGNC:59717