EIF4E2 - eukaryotic translation initiation factor 4E family member 2 Gene

Homo sapiens

Also known as 4EHP; IF4e; 4E-LP; h4EHP; EIF4EL3

Gene ID: 9470 | Gene type: protein coding

About EIF4E2

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:232,550,689-232,583,644 (from NCBI)

This gene has 17 transcripts (splice variants), 250 orthologues and 3 paralogues. Ubiquitous expression in kidney (RPKM 16.4), colon (RPKM 13.5) and 25 other tissues.

Summary

Enables ubiquitin protein ligase binding activity. Involved in positive regulation of miRNA mediated inhibition of translation. Acts upstream of or within negative regulation of translation. Located in P-body. Part of mRNA cap binding activity complex. [provided by Alliance of Genome Resources, Apr 2022]

EIF4E2 Products(7)

mRNA	Protein	Name
NM_001276336.2	NP_001263265.1	eukaryotic translation initiation factor 4E type 2 isoform C
NM_001276337.2	NP_001263266.1	eukaryotic translation initiation factor 4E type 2 isoform D
NM_001282958.2	NP_001269887.1	eukaryotic translation initiation factor 4E type 2 isoform B
NM_001330201.2	NP_001317130.1	eukaryotic translation initiation factor 4E type 2 isoform E
NM_001330202.2	NP_001317131.1	eukaryotic translation initiation factor 4E type 2 isoform G
NM_001330203.2	NP_001317132.1	eukaryotic translation initiation factor 4E type 2 isoform F
NM_004846.4	NP_004837.1	eukaryotic translation initiation factor 4E type 2 isoform A

EIF4E2 Protein Structure

IF4E

0
100
200
245 a.a.

Protein Preferred Names

Protein Names

eukaryotic translation initiation factor 4E type 2

eIF-4E type 2

Related Diseases

Diseases

Alias

Coffin-Siris Syndrome 2

CSS2	Mrd14
Mental Retardation, Autosomal Dominant 14	Autosomal Dominant Mental Retardation 14
Coffin-Siris Syndrome, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04275	EIF4E2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	EIF4E2	MGD	MGI:1914440
Rattus norvegicus	EIF4E2	RGD	RGD:1307790
Bos taurus	EIF4E2	VGNC	VGNC:28410
Macaca mulatta	EIF4E2	VGNC	VGNC:72194

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