MAPK8IP1 - mitogen-activated protein kinase 8 interacting protein 1 Gene

Homo sapiens

Also known as IB1; JIP1; JIP-1; PRKM8IP

Gene ID: 9479 | Gene type: protein coding

About MAPK8IP1

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:45,885,651-45,906,465 (from NCBI)

This gene has 3 transcripts (splice variants), 285 orthologues, 11 paralogues and is associated with 1 phenotype. Biased expression in brain (RPKM 54.8), testis (RPKM 11.7) and 5 other tissues.

Summary

This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced Apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq, May 2011]

MAPK8IP1 Products(1)

mRNA	Protein	Name
NM_005456.4	NP_005447.1	C-Jun-amino-terminal kinase-interacting protein 1

MAPK8IP1 Protein Structure

SH3_9

PID

0
200
400
600
711 a.a.

Protein Preferred Names

Protein Names

C-Jun-amino-terminal kinase-interacting protein 1

IB-1

Related Diseases

Diseases

Alias

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Papillary Squamous Carcinoma

Papillary Epidermoid Carcinoma

Papillary Squamous Cell Carcinoma

Cervix Erosion

Erosion Of Cervix

Uterine Cervical Erosion

Cervical Adenosquamous Carcinoma

Adenosquamous Carcinoma Of Cervix

Adenosquamous Cell Carcinoma Of The Cervix Uteri

Lymphocele

Lymph Cyst

Lymphocele Adverse Event

Cervix Small Cell Carcinoma

Small Cell Carcinoma Of The Cervix

Small Cell Carcinoma Of The Cervix Uteri

Ischemia

Acute Coronary Syndrome

Vaginal Cancer

Malignant Neoplasm Of Vagina	Vaginal Neoplasms
Malignant Tumor Of Vagina	Malignant Vaginal Tumor
Neoplasm Of Vagina	Vagina Neoplasm
Vaginal Tumor	Vaginal Carcinoma
Vaginal Malignant Epithelial Tumor	Vaginal Neoplasm
Malignant Vaginal Neoplasm	Vagina Carcinoma
Vaginal Neoplasia	Cancer Of Vagina
Malignant Tumour Of Vagina	Carcinoma Of Vagina
Primary Malignant Neoplasm Of Vagina	Vagina Wall Cancer
Vaginal Wall Cancer

Hemometra

Hematometra

Cervical Clear Cell Adenocarcinoma

Clear Cell Carcinoma Of The Cervix Uteri

Cervix Endometriosis

Endometriosis Of Cervix

Cervical Endometriosis

Sigmoid Disease

Sigmoid Diseases

Cervical Incompetence

Uterine Cervical Incompetence

Vaginal Discharge

Cervical Adenoid Basal Carcinoma

Cervical Carcinosarcoma

Cervical Malignant Mixed Mesodermal Mullerian Tumor	Cervical Malignant Mixed Mullerian Tumor
Cervical Mixed Epithelial And Mesenchymal Neoplasm

Cervical Mucinous Adenocarcinoma

Isthmus Cancer

Endocervical Carcinoma

Carcinoma Of Endocervix

Carcinoma Of The Endocervix

Radiation Cystitis

Irradiation Cystitis

Cervix Carcinoma

Cancer Of Cervix	Carcinoma Of Cervix
Carcinoma Cervix Uteri	Carcinoma Of The Cervix Uteri

Cervical Polyp

Cervix Adenomatous Polyp

Uterus Carcinoma In Situ

Anal Canal Squamous Cell Carcinoma

Squamous Cell Carcinoma Of The Anal Canal

Cervix Uteri Carcinoma In Situ

Carcinoma In Situ Of Cervix	Carcinoma In Situ Of Uterine Cervix
Cervical Intraepithelial Neoplasia	Carcinoma Of Cervix Stage 0
Cervical Intraepithelial Neoplasia Grade Iii With Severe Dysplasia	Cervix Ca In Situ
Cin Iii	Cin Iii - Carcinoma In Situ Of Cervix
Cin Iii - Severe Dyskaryosis	Severe Dysplasia Of Cervix
Severe Dysplasia Of The Cervix Uteri	Squamous Intraepithelial Neoplasia, Grade Iii
Cervix Intraepithelial Neoplasia Grade 3 Ajcc V7

Cancerophobia

Cancer Phobia

Fear Of Getting Cancer

Adenosquamous Carcinoma

Adenosquamous Cell Carcinoma	Mixed Adenocarcinoma And Squamous Carcinoma
Carcinoma Adenosquamous	Carcinoma, Adenosquamous

Ovarian Melanoma

Nosophobia

Botryoid Rhabdomyosarcoma

Sarcoma Botryoides	Botryoid Sarcoma
Botryoid-Type Embryonal Rhabdomyosarcoma

Adenocarcinoma In Situ

Cervical Adenocarcinoma

Adenocarcinoma Cervix Uteri	Adenocarcinoma Of Cervix
Adenocarcinoma Of The Uterine Cervix	Adenocarcinoma Of The Cervix Uteri

Endocervical Adenocarcinoma

Endocervical Carcinoma

Endometrial Small Cell Carcinoma

Cervix Disease

Uterine Cervical Diseases	Cervix Disorders
Cervix Diseases

Vaginal Disease

Vaginal Diseases

Cervical Adenosarcoma

Cervical Muellerian Adenosarcoma

Cervical Mullerian Adenosarcoma

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08124	MAPK8IP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MAPK8IP1	VGNC	VGNC:49920
Mus musculus	MAPK8IP1	MGD	MGI:1309464
Felis catus	MAPK8IP1	VGNC	VGNC:82019
Rattus norvegicus	MAPK8IP1	RGD	RGD:70937
Bos taurus	MAPK8IP1	VGNC	VGNC:31224
Macaca mulatta	MAPK8IP1	VGNC	VGNC:74650