KLK4 - kallikrein related peptidase 4 Gene

Homo sapiens

Also known as ARM1; EMSP; PSTS; AI2A1; EMSP1; KLK-L1; PRSS17; kallikrein

Gene ID: 9622 | Gene type: protein coding

About KLK4

Cytogenetic location: 19q13.41 Genomic coordinates (GRCh38): 19:50,906,351-50,911,395 (from NCBI)

This gene has 8 transcripts (splice variants), 105 orthologues, 12 paralogues and is associated with 2 phenotypes. Restricted expression toward prostate (RPKM 123.8).

Summary

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel Cancer and Other disease biomarkers. This gene is one of the fifteen Kallikrein subfamily members located in a cluster on chromosome 19. In some tissues its expression is hormonally regulated. The expression pattern of a similar mouse protein in murine developing teeth supports a role for the protein in the degradation of enamel proteins. Several transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Dec 2014]

KLK4 Products(2)

mRNA	Protein	Name
NM_001302961.2	NP_001289890.1	kallikrein-4 isoform 2
NM_004917.5	NP_004908.4	kallikrein-4 isoform 1 preproprotein

KLK4 Protein Structure

Trypsin

0
100
200
254 a.a.

Protein Preferred Names

Protein Names

kallikrein-4

androgen-regulated message 1

Recombinant KLK4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70947	Kallikrein-4 Protein, Human (H197Q, HEK293, His)	Q9Y5K2 (S27-S254, H197Q)	≥95%
HY-P77431	Kallikrein-4 Protein, Human (254a.a, HEK293, His)	Q9Y5K2 (M1-S254)	≥95%

Related Diseases

Diseases

Alias

Amelogenesis Imperfecta, Hypomaturation Type, Iia1

AI2A1	Amelogenesis Imperfecta, Pigmented Hypomaturation Type, 1
Amelogenesis Imperfecta, Type Iia1	Amelogenesis Imperfecta, Hypomaturation Type, 2a1
Aiph	Amelogenesis Imperfecta 2 Hypocalcification Type
Amelogenesis Imperfecta Hypomineralization Type	Amelogenesis Imperfecta Pigmented Hypomaturation Type 1

Amelogenesis Imperfecta Type 2a1

Ai2a1	Amelogenesis Imperfecta Pigmented Hypomaturation Type 1
Amelogenesis Imperfecta Type Iia1	Amelogenesis Imperfecta, Hypomaturation Type, Iia1

Amelogenesis Imperfecta

Ai	Congenital Enamel Hypoplasia
Al - [Amelogenesis Imperfecta]

Amelogenesis Imperfecta Hypomaturation Type

Aih	Hypomaturation Amelogenesis Imperfecta
Amelogenesis Imperfecta Type 2

Amelogenesis Imperfecta, Type Iiia

Ai3	Adhcai
Amelogenesis Imperfecta Type 3	AI3A
Amelogenesis Imperfecta, Type Iii	Amelogenesis Imperfecta, Hypocalcification Type, Autosomal Dominant
Amelogenesis Imperfecta Type 3a	Amelogenesis Imperfecta Hypomineralization Type
Amelogenesis Imperfecta Type Iii	Hypocalcified Amelogenesis Imperfecta
Amelogenesis Imperfecta, Type 3	Amelogenesis Imperfecta, Hypomineralization Type
Autosomal Dominant Amelogenesis Imperfecta Hypocalcification Type	Amelogenesis Imperfecta 3a
Amelogenesis Imperfecta Hypocalcification Type Autosomal Dominant

Prosopagnosia

C1 Inhibitor Deficiency

Quincke Edema	Angioedemas, Hereditary
Angioedema

Angioedema, Hereditary, 3

Angioedema, Hereditary, Type Iii	Hereditary Angioedema Type Iii
Hereditary Angioedema Type 3	HAE3
Estrogen-Related Hae	Estrogen-Sensitive Hae
Angioneurotic Edema, Hereditary, With Normal C1 Inhibitor Concentration And Function	Hae With Normal C1 Inhibitor Concentration And Function
Hereditary Angioedema With Normal C1 Inhibitor Activity	F12-Related Hereditary Angioedema With Normal C1inh
F12-Related Hae With Normal C1 Inhibitor	Hae 3
Hae-Iii	Hereditary Angioneurotic Edema Type 3
Inherited Estrogen-Associated Angioedema	Inherited Estrogen-Associated Angioneurotic Edema
Inherited Estrogen-Dependent Angioedema	Inherited Estrogen-Dependent Angioneurotic Edema
Angioneurotic Edema Hereditary With Normal C1 Inhibitor Concentration And Function	Hereditary Angioedema With Normal C1 Esterase Inhibitor Activity

High Molecular Weight Kininogen Deficiency

HMWK DEFICIENCY	Fitzgerald Trait
Congenital High-Molecular-Weight Kininogen Deficiency	Flaujeac Factor Deficiency
Kininogen Deficiency, High Molecular Weight	Kininogen Deficiency
Hmwk	High-Molecular-Weight Kininogen Deficiency, Congenital

Acquired Angioedema

Acquired C1 Inhibitor Deficiency	Angioedema, Acquired
Aae	Acquired Angioneurotic Edema
Acquired Bradykinine-Induced Angioedema	Acquired Non Histamine-Induced Angioedema
Acquired Angioneurotic Oedema	Aae - [Acquired Angioneurotic Oedema]

Dental Caries

Dental Caries Extending Into Pulp	Dental Caries Of Smooth Surface
Dental Caries Pit And Fissure	Smooth Surface Dental Caries
Dental Decay	Carious Teeth
Dental Cavity	Saprodontia
Teeth Decayed	Tooth Caries
Tooth Decay

Parotid Disease

Parotid Diseases

Autotopagnosia

Body-Image Agnosia

Pyruvate Kinase Deficiency Of Red Cells

Pyruvate Kinase Deficiency	Pk Deficiency
Pyruvate Kinase Deficiency Of Erythrocyte	Hemolytic Anemia Due To Red Cell Pyruvate Kinase Deficiency
Pyruvate Kinase Deficiency Of Erythrocytes	Pkd
PKRD	Hereditary Non-Spherocytic Hemolytic Anemia Due To Pyruvate Kinase Deficiency
Hnsha	Pyruvate Kinase-Deficient Hemolytic Anemia
Red Cell Pyruvate Kinase Deficiency	Deficiency Of Pyruvate Kinase
Anemia, Hemolytic, Congenital Nonspherocytic

Hereditary Angioedema

Hereditary Angioneurotic Edema	Hereditary Angioedema Type 1
Hane	Angioedema, Hereditary
Hae	Angioedemas, Hereditary
Deficiency Of C1 Esterase Inhibitor	C1 Esterase Inhibitor Deficiency
C1 Inhibitor Deficiency	Familial Angioneurotic Edema
Hereditary Bradykinine-Induced Angioedema	Hereditary Non Histamine-Induced Angioedema
Hae 1	Hae-I
Hereditary Angioneurotic Edema Type 1	Hereditary C1 Esterase Inhibitor Deficiency - Deficient Factor
Hereditary Angioedema Types I And Ii	Hereditary Angioneurotic Oedema
Familial Angioedema	Hae - [Hereditary Angioneurotic Oedema]
Bannister Disease, Hereditary	Quincke Disease Or Oedema
Hereditary Quincke Oedema

Dental Fluorosis

Mottled Teeth	Intrinsic Enamel Discolouration Of Fluorosis
Mottling Of Enamel	Fluorosis, Dental
Dental Fluorosis, Acquired

Congenital Nonspherocytic Hemolytic Anemia

Hereditary Non-Spherocytic Hemolytic Anemia	Hereditary Nonspherocytic Hemolytic Anemia
Anemia, Hemolytic, Congenital Nonspherocytic	Congenital Nonspherocytic Hemolytic Anaemia
Hereditary Nonspherocytic Hemolytic Anaemia	Hnsha

Factor Xii Deficiency

Hageman Factor Deficiency	Haf Deficiency
Factor Xii Deficiency Disease	F12 Deficiency
Deficiency, Hageman	Coagulation Factor 12 Deficiency
Factor 12 Deficiency	Congenital Factor Xii Deficiency
Congenital Hageman Factor Deficiency	FA12D
Factor Xii	Deficiency, Factor Xii

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Netherton Syndrome

NETH	Ns
Netherton Disease	Comel-Netherton Syndrome
Erythroderma, Ichthyosiform, With Hypotrichosis And Hyper-Ige	Bamboo Hair Syndrome
Ichthyosis Linearis Circumflexa	Ichthyosiform Erythroderma With Hypotrichosis And Hyper-Ige
Ilc	Nts
N Syndrome

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Parotitis

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Renovascular Hypertension

Hypertension, Renovascular

Hypertension Renovascular

Endometrial Cancer

Endometrial Carcinoma	Endometrial Neoplasm
Malignant Neoplasm Of Endometrium	Endometrioid Carcinoma
Endometrial Neoplasms	Carcinoma, Endometrioid
Endometrial Cancer, Familial	Endometrial Carcinoma, Somatic
Endometrial Cancer, Susceptibility To	Endometrial Ca
Malignant Endometrial Neoplasm	Neoplasm Of Endometrium
Primary Malignant Neoplasm Of Endometrium	Tumor Of Endometrium
Carcinoma Of The Endometrium	Endometrioid Carcinoma Of Female Reproductive System
ENDMC	Carcinoma Endometrioid
Endometrial Cancers	Cancer, Endometrial
Uterine Corpus Cancer

Teeth Hard Tissue Disease

Renal Hypertension

Hypertension Renal

Hypertension, Renal

Bladder Tuberculosis

Tuberculous Cystitis

Tuberculosis Of Bladder

Conn'S Syndrome

Cushing Syndrome	Hyperaldosteronism
Primary Hyperaldosteronism	Hypercortisolism
Primary Aldosteronism	Cushing'S Syndrome
Adrenal Gland Hyperfunction	Conn Syndrome
Hyperadrenalism	Ectopic Acth Syndrome
Hyperadrenocorticism	Cushing Disease
Cushing'S Disease	Adrenal Cortex Adenoma
Corticotroph Pituitary Adenoma	Pituitary Corticotroph Micro-Adenoma
Pituitary-Dependent Cushing Syndrome	Pituitary Acth Hypersecretion
Acth Syndrome, Ectopic	Acth-Secreting Pituitary Adenoma
Adrenal Hyperfunction Resulting From Pituitary Acth Excess	Ectopic Adrenocorticotropic Hormone Syndrome
Nodular Primary Adrenocortical Dysplasia	Pituitary Dependent Cushing Syndrome
Pituitary Cushing Syndrome	Pituitary-Dependant Cushing Syndrome
Pituitary-Dependant Hypercortisolism	Pituitary-Dependant Hypercortisolism Disorder
Aldosteronism Primary	Acth Syndrome Ectopic
Adrenal Cushing'S Syndrome	Adrenal Cortical Adenoma
Cushing Syndrome Nos	Cortisol Hypersecretion
Corticoadrenal Hypersecretion	Cushing Syndrome Secondary To Ectopic Acth-Secretion
Ectopic Cushing Syndrome	Hypercortisolism Due To Nonpituitary Tumour
Ectopic Acth - [Adrenocorticotropic Hormone] Secretion	Ectopic Acth - [Adrenocorticotropic Hormone] Secretion Causing Cushing Syndrome
Idiopathic Aldosteronism	Aldosteronism
Primary Aldosteronism Due To Bilateral Adrenal Hyperplasia	Primary Aldosteronism Due To Adrenal Hyperplasia

Bartter Disease

Bartter Syndrome	Bartter'S Syndrome
Aldosteronism With Hyperplasia Of The Adrenal Cortex	Hypokalemic Alkalosis With Hypercalciuria
Potassium Wasting	Juxtaglomerular Hyperplasia With Secondary Aldosteronism
Renal Tubular Normotensive Hypokalemic Alkalosis With Hypercalciuria	Salt-Losing Tubular Disorder, Henle'S Loop Type
Salt-Wasting Tubulopathy, Henle'S Loop Type	Bartters Syndrome

Akinetopsia

Combined Oxidative Phosphorylation Deficiency 33

COXPD33

Pituitary Adenoma 2, Growth Hormone-Secreting

PITA2	Acromegaly Due To Pituitary Adenoma 2
Acromegaly, X-Linked	Growth Hormone Secreting Pituitary Adenoma 2
Pituitary Adenoma, Growth Hormone-Secreting, 2	Pituitary Adenoma 2, Gh-Secreting
Gh-Secreting Pituitary Adenoma 2	X-Linked Acromegaly
Adenoma, Pituitary, Growth Hormone-Secreting, Type 2

Autosomal Recessive Congenital Ichthyosis

Lamellar Ichthyosis	Congenital Ichthyosiform Erythroderma
Li	Congenital Nonbullous Ichthyosiform Erythroderma
Arci	Congenital Lamellar Ichthyosis
Nonbullous Congenital Ichthyosiform Erythroderma	Cie
Congenital Non-Bullous Ichthyosiform Erythroderma	Erythrodermic Ichthyosis
Nbcie	Ncie
Non-Bullous Congenital Ichthyosiform Erythroderma	Collodion Baby
Ichthyosis, Lamellar	Non Bullous Congenital Ichthyosiform Erythroderma
Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form	Ichthyosiform Erythroderma, Congenital, Nonbullous, 1
Collodion Baby Syndrome	Ichthyoses, Lamellar
Nbie	Nonbullous Ichthyosiform Erythroderma
Classic Lamellar Ichthyosis	Ichthyosiform Erythroderma Nonbullous Congenital
Ichthyosiform Erythroderma Congenital	Ichthyosis, Congenital, Autosomal Recessive
Ichthyosiform Erythroderma, Congenital	Collodion Fetus
Non-Bullous Ichthyosiform Erythroderma

Skin Disease

Skin Diseases	Genodermatosis
Abnormality Of The Skin	Skin Diseases, Genetic
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07382	KLK4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KLK4	MGD	MGI:1861379
Felis catus	KLK4	VGNC	VGNC:67964
Canis familiaris	KLK4	VGNC	VGNC:42482
Rattus norvegicus	KLK4	RGD	RGD:1303228
Bos taurus	KLK4	VGNC	VGNC:30678
Others	KLK4	NCBI