2. Gene
  3. MICAL2 - microtubule associated monooxygenase, calponin and LIM domain containing 2 Gene

MICAL2 - microtubule associated monooxygenase, calponin and LIM domain containing 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MICAL-2; MICALCL; Ebitein1; mical-cL; MICAL2PV1; MICAL2PV2

Gene ID: 9645 | Gene type: protein coding

About MICAL2

Cytogenetic location: 11p15.3 Genomic coordinates (GRCh38): 11:12,110,590-12,362,140 (from NCBI)

This gene has 37 transcripts (splice variants), 292 orthologues and 36 paralogues. Broad expression in testis (RPKM 23.1), colon (RPKM 17.9) and 24 other tissues.

Summary

The protein encoded by this gene is a monooxygenase that enhances depolymerization of F-actin and is therefore involved in cytoskeletal dynamics. The encoded protein is a regulator of the SRF signaling pathway. Increased expression of this gene has been associated with Cancer progression and metastasis. [provided by RefSeq, Oct 2016]

MICAL2 Products(16)

mRNA Protein Name
NM_001282663.2 NP_001269592.1 [F-actin]-monooxygenase MICAL2 isoform a
NM_001282664.1 NP_001269593.1 [F-actin]-monooxygenase MICAL2 isoform b
NM_001282665.1 NP_001269594.1 [F-actin]-monooxygenase MICAL2 isoform c
NM_001282666.1 NP_001269595.1 [F-actin]-monooxygenase MICAL2 isoform d
NM_001282667.1 NP_001269596.1 [F-actin]-monooxygenase MICAL2 isoform e
NM_001282668.2 NP_001269597.1 [F-actin]-monooxygenase MICAL2 isoform f
NM_001346292.2 NP_001333221.1 [F-actin]-monooxygenase MICAL2 isoform a
NM_001346293.2 NP_001333222.1 [F-actin]-monooxygenase MICAL2 isoform b
NM_001346294.2 NP_001333223.1 [F-actin]-monooxygenase MICAL2 isoform b
NM_001346295.2 NP_001333224.1 [F-actin]-monooxygenase MICAL2 isoform b
NM_001346296.2 NP_001333225.1 [F-actin]-monooxygenase MICAL2 isoform b
NM_001346297.2 NP_001333226.1 [F-actin]-monooxygenase MICAL2 isoform b
NM_001346298.2 NP_001333227.1 [F-actin]-monooxygenase MICAL2 isoform b
NM_001346299.2 NP_001333228.1 [F-actin]-monooxygenase MICAL2 isoform b
NM_001393937.1 NP_001380866.1 [F-actin]-monooxygenase MICAL2 isoform g
NM_014632.4 NP_055447.1 [F-actin]-monooxygenase MICAL2 isoform a

MICAL2 Protein Structure

FAD_binding_3

FAD_binding_3: FAD binding domain (87 - 124)

CH

CH: Calponin homology (CH) domain (521 - 621)

LIM

LIM: LIM domain (1002 - 1058)

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  • 1124 a.a.
Protein Preferred Names Protein Names

[F-actin]-monooxygenase MICAL2

ERK2-binding testicular protein 1

Recombinant MICAL2 Proteins

Cat. No. Product Name Accession Purity
HY-P71756 MICAL2 Protein, Human (P.pastoris, His) O94851 (1M-495H) ≥95%

Related Diseases

Diseases Alias
Trimethylaminuria

TMAU

Fish-Odor Syndrome

Fish Malodor Syndrome

Fish Odor Syndrome

Stale Fish Syndrome

Tmauria

Severe Primary Trimethylaminuria

Mesh

D008661

Fish Odour Syndrome
Griscelli Syndrome

Chediak-Higashi-Like Syndrome

Griscelli-Prunieras Syndrome

Partial Albinism-Immunodeficiency Syndrome

Griscelli Disease

Gs

Hypopigmentation Immunodeficiency Disease

Partial Albinism With Immunodeficiency

Immunodeficiency Syndrome With Hypopigmentation

Hypopigmentation-Immunodeficiency Disease
Mitral Valve Insufficiency

Mitral Regurgitation

Congenital Insufficiency Of Mitral Valve

Congenital Mitral Insufficiency

Congenital Mitral Regurgitation

Mitral Valve Incompetence

Mitral Valve Regurgitation

Mr - [Mitral Regurgitation]

Mi - [Mitral Incompetence]

Mitral Valve Annular Incompetency

Congenital Mitral Valve Incompetence

Congenital Mitral Valve Insufficiency

Congenital Mitral Valve Regurgitation

Congenital Mitral Incompetence
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-P0107 RC-3095 Antagonist / Phase 2
Pre-clinical Phase
Bioactive Molecules (14)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P0107A RC-3095 TFA Antagonist 98.12% Unkown
HY-103316A Ned 19 Inhibitor 99.92% Unkown
HY-12736A GSK143 dihydrochloride Inhibitor 99.73% Unkown
HY-109506S DPPC-d62 ≥99.0% Unkown
HY-109506S1 DPPC-d9 ≥95.0% Unkown
HY-131102 Mequindox Inhibitor 99.67% Unkown
HY-145119S Mindeudesivir 99.02% Unkown
HY-101139 Xanthine amine congener Antagonist / Unkown
HY-109506S3 DPPC-d9-1 / Unkown
HY-12736 GSK143 Inhibitor / Unkown
HY-B0448S1 Phenytoin-15n2,13c / Unkown
HY-D0195S Acesulfame-d4 potassium / Unkown
HY-N1428S3 Citric acid-13C3 / Unkown
HY-RS08426 MICAL2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus MICAL2 VGNC VGNC:103135
Macaca mulatta MICAL2 VGNC VGNC:101352
Bos taurus MICAL2 VGNC VGNC:31458
Rattus norvegicus MICAL2 RGD RGD:1311773
Canis familiaris MICAL2 VGNC VGNC:106605
Mus musculus MICAL2 MGD MGI:2444947
Others MICAL2 NCBI