DHX34 - DExH-box helicase 34 Gene

Homo sapiens

Also known as HRH1; DDX34

Gene ID: 9704 | Gene type: protein coding

About DHX34

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:47,349,315-47,382,704 (from NCBI)

This gene has 4 transcripts (splice variants), 189 orthologues, 18 paralogues and is associated with 1 phenotype. Broad expression in testis (RPKM 9.0), bone marrow (RPKM 4.3) and 25 other tissues.

Summary

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. It is mapped to the glioma 19q tumor suppressor region and is a tumor suppressor candidate gene. [provided by RefSeq, Jul 2008]

DHX34 Products(1)

mRNA	Protein	Name
NM_014681.6	NP_055496.2	probable ATP-dependent RNA helicase DHX34

DHX34 Protein Structure

DEAD

Helicase_C

HA2

OB_NTP_bind

0
200
400
600
800
1000
1143 a.a.

Protein Preferred Names

Protein Names

probable ATP-dependent RNA helicase DHX34

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 34

Related Diseases

Diseases

Alias

Pulmonary Emphysema

Renal Hypodysplasia/Aplasia 3

RHDA3	Renal Agenesis, Unilateral
Unilateral Renal Agenesis

Polydactyly, Postaxial, Type A1

Postaxial Polydactyly Type A	Polydactyly, Postaxial
Postaxial Polydactyly	PAPA1
Postaxial Polydactyly, Type A	Papa
Polydactyly, Postaxial, Types A1 And B	Postaxial Polydactyly Type B
Polydactyly Postaxial	Polydactyly, Postaxial A1
Polydactyly, Postaxial B	PAPB
Postaxial Polydactyly, Type A1/B	Polydactyly, Postaxial, Type A
Pyogenic Arthritis, Pyoderma Gangrenosum And Acne	Postaxial Polydactyly, Type B

Polycystic Kidney Disease

Polycystic Kidney Diseases	Pkd
Polycystic Renal Disease	Kidney Disease, Polycystic
Polycystic Kidney, Autosomal Dominant

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Immunodeficiency 51

IMD51	Candf5
Candidiasis, Familial, 5	Candidiasis, Familial, 5, Formerly
Candf5, Formerly	Familial Candidiasis 5
Candidiasis Familial 5 Autosomal Recessive	Candidiasis Familial Chronic Mucocutaneous Autosomal Recessive
Chronic Mucocutaneous Candidiasis 5

Pelger-Huet Anomaly

PHA	Pelger-Huët Anomaly
Ovoid Neutrophil Nuclei, Developmental Delay, Epilepsy And Skeletal Abnormalities	Pelger Huet Anomaly
Pelger-Huet Nuclear Anomaly

Pancreatic Adenosquamous Carcinoma

Adenosquamous Carcinoma Of Pancreas

Adenosquamous Carcinoma Of The Pancreas

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03753	DHX34 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DHX34	VGNC	VGNC:71634
Felis catus	DHX34	VGNC	VGNC:61479
Mus musculus	DHX34	MGD	MGI:1918973
Rattus norvegicus	DHX34	RGD	RGD:1584452
Canis familiaris	DHX34	VGNC	VGNC:39944
Bos taurus	DHX34	VGNC	VGNC:28052

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