2. Gene
  3. DCAF1 - DDB1 and CUL4 associated factor 1 Gene

DCAF1 - DDB1 and CUL4 associated factor 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as RIP; VPRBP

Gene ID: 9730 | Gene type: protein coding

About DCAF1

Cytogenetic location: 3p21.2 Genomic coordinates (GRCh38): 3:51,395,867-51,505,639 (from NCBI)

This gene has 4 transcripts (splice variants) and 254 orthologues. Broad expression in testis (RPKM 27.5), thyroid (RPKM 8.3) and 24 other tissues.

Summary

Enables Estrogen Receptor binding activity and histone kinase activity (H2A-T120 specific). Involved in cell competition in a multicellular organism; histone H2A-T120 phosphorylation; and negative regulation of transcription by RNA polymerase II. Located in fibrillar center and nucleoplasm. Part of Cul4-RING E3 ubiquitin ligase complex. Colocalizes with COP9 signalosome. [provided by Alliance of Genome Resources, Apr 2022]

DCAF1 Products(12)

mRNA Protein Name
NM_001171904.2 NP_001165375.1 DDB1- and CUL4-associated factor 1 isoform 2
NM_001349168.2 NP_001336097.1 DDB1- and CUL4-associated factor 1 isoform 1
NM_001349169.2 NP_001336098.1 DDB1- and CUL4-associated factor 1 isoform 1
NM_001349170.2 NP_001336099.1 DDB1- and CUL4-associated factor 1 isoform 1
NM_001349171.2 NP_001336100.1 DDB1- and CUL4-associated factor 1 isoform 3
NM_001387578.1 NP_001374507.1 DDB1- and CUL4-associated factor 1 isoform 1
NM_001387579.1 NP_001374508.1 DDB1- and CUL4-associated factor 1 isoform 1
NM_001387580.1 NP_001374509.1 DDB1- and CUL4-associated factor 1 isoform 1
NM_001387581.1 NP_001374510.1 DDB1- and CUL4-associated factor 1 isoform 1
NM_001387582.1 NP_001374511.1 DDB1- and CUL4-associated factor 1 isoform 2
NM_001387583.1 NP_001374512.1 DDB1- and CUL4-associated factor 1 isoform 3
NM_014703.3 NP_055518.1 DDB1- and CUL4-associated factor 1 isoform 1
Protein Preferred Names Protein Names

DDB1- and CUL4-associated factor 1

HIV-1 Vpr-binding protein

Related Diseases

Diseases Alias
Intraorbital Meningioma
Neurilemmomatosis

Schwannomatosis

Neurofibromatosis Type 3

Nf3

Neurilemmomatosis Congenital Cutaneous

Neurinomatosis

Congenital Cutaneous Neurilemmomatosis

Multiple Neurilemmomas

Multiple Schwannomas

Neurilemmomatosis, Congenital Cutaneous

Schwannomatosis 1

Neurofibromatosis 3

Mixed Central And Peripheral Neurofibromatosis

Nf3 - [Neurofibromatosis Type 3]
Meningioma, Familial

Meningioma

Familial Meningioma

Meningioma, Familial, Susceptibility To

Meningeal Neoplasm

Meningeal Neoplasms

Meningiomas

Meningioma, Nf2-Related, Somatic

Meningioma, Sis-Related

Meningothelial Cell Tumor

Neoplasm Of The Meninges

Primary Meningeal Tumor

Familial Multiple Meningioma

MNGMA

Meningioma, Benign, No Icd-O Subtype

Intracranial Meningioma

Meningothelial Cell Neoplasm

Supratentorial Meningioma

Primary Neoplasm Of Spinal Meninges

Benign Intracranial Meningioma

Benign Meningioma

Meningeal Tumours

Meningeal Sarcoma Of Unspecified Site

Meningothelial Sarcoma Of Unspecified Site
Acoustic Neuroma

Neurofibromatosis Type 2

Vestibular Schwannoma

Acoustic Neurinoma

Bilateral Acoustic Neurofibromatosis

Nf2

Acoustic Neurilemoma

Cerebellopontine Angle Tumor

Neurofibromatosis Central Type

Neurofibromatosis Type Ii

Vestibular Neurilemmoma

Acoustic Tumor

Neurinoma Of The Acoustic Nerve

Acoustic Neurinoma Bilateral

Acoustic Schwannomas Bilateral

Banf

Central Neurofibromatosis

Familial Acoustic Neuromas

Neurofibromatosis 2

Neurofibromatosis Type 2 Merlin

Schwannoma, Acoustic, Bilateral

Neuroma Acoustic

Neuroma, Acoustic

Familial Acoustic Neuroma

Familial Vestibular Schwannoma

Neurofibromatosis, Central Type

Nf2 - [Neurofibromatosis Type 2]
Neurofibromatosis, Type Ii

Neurofibromatosis 2

Neurofibromatosis, Type 2

NF2

Neurofibromatosis Type Ii

Bilateral Acoustic Neurofibromatosis

Banf

Acn

Central Neurofibromatosis

Neurofibromatosis, Central Type

Acoustic Schwannomas, Bilateral

Acoustic Neurinoma, Bilateral

Bilateral Acoustic Neurinoma

Bilateral Acoustic Schwannomas

Familial Acoustic Neuromas
Cockayne Syndrome A

Cockayne Syndrome Type 1

Cockayne Syndrome, Type A

Cockayne Syndrome Type I

CSA

Cockayne Syndrome Classic Form

Cockayne Syndrome Classical

Cockayne Syndrome Type A

Ckn1
Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome

Cree Encephalitis

Aicardi-Goutières Syndrome

Encephalopathy With Basal Ganglia Calcification

Ags

Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid

Pseudotoxoplasmosis Syndrome

Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis

Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis

Aicardi-Goutieres Syndrome 1
Neurilemmoma

Schwannoma

Benign Schwannoma

Neurilemoma

Peripheral Fibroblastoma

Psammomatous Schwannoma

Neurolemmoma

Schwannomas
Lissencephaly

Pachygyria

Broad Gyri Of Cerebrum

Large Gyri Of Cerebrum

Macrogyria
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-149934 DCAF1 binder 1 99.12% Unkown
HY-149307 CYCA-117-70 / Unkown
HY-149935 OICR-8268 / Unkown
HY-RS03557 DCAF1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-156743 DCAF1 binder 2 / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta DCAF1 VGNC VGNC:71819
Canis familiaris DCAF1 VGNC VGNC:39788
Felis catus DCAF1 VGNC VGNC:61353
Mus musculus DCAF1 MGD MGI:2445220
Bos taurus DCAF1 VGNC VGNC:27899
Rattus norvegicus DCAF1 RGD RGD:1305176
Others DCAF1 NCBI