2. Gene
  3. DELE1 - DAP3 binding cell death enhancer 1 Gene

DELE1 - DAP3 binding cell death enhancer 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DELE; DELE1(L); KIAA0141

Gene ID: 9812 | Gene type: protein coding

About DELE1

Cytogenetic location: 5q31.3 Genomic coordinates (GRCh38): 5:141,923,871-141,942,047 (from NCBI)

This gene has 7 transcripts (splice variants), 202 orthologues and 4 paralogues. Ubiquitous expression in heart (RPKM 16.6), spleen (RPKM 16.6) and 25 other tissues.

Summary

Enables protein kinase binding activity and protein serine/threonine kinase activator activity. Involved in HRI-mediated signaling; extrinsic apoptotic signaling pathway via death domain receptors; and regulation of cysteine-type endopeptidase activity involved in apoptotic process. Located in cytosol and mitochondrial inner membrane. [provided by Alliance of Genome Resources, Apr 2022]

DELE1 Products(2)

mRNA Protein Name
NM_001142603.3 NP_001136075.1 death ligand signal enhancer precursor
NM_014773.5 NP_055588.3 death ligand signal enhancer precursor

DELE1 Protein Structure

Sel1

Sel1: Sel1 repeat (260 - 276)

Sel1

Sel1: Sel1 repeat (277 - 312)

Sel1

Sel1: Sel1 repeat (314 - 349)

Sel1

Sel1: Sel1 repeat (352 - 384)

Sel1

Sel1: Sel1 repeat (386 - 420)

  • 0
  • 100
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  • 400
  • 515 a.a.
Protein Preferred Names Protein Names

death ligand signal enhancer

DAP3-binding cell death enhancer 1, long form

Related Diseases

Diseases Alias
Pulmonary Adenocarcinoma In Situ

Bronchioalveolar Carcinoma
Lung Carcinoma In Situ
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-149543 BTM-3528 / Unkown
HY-RS03684 DELE1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus DELE1 MGD MGI:1914089
Rattus norvegicus DELE1 RGD RGD:735029
Bos taurus DELE1 VGNC VGNC:50135
Macaca mulatta DELE1 VGNC VGNC:71806
Felis catus DELE1 VGNC VGNC:61431
Canis familiaris DELE1 VGNC VGNC:53268