2. Gene
  3. ARHGEF11 - Rho guanine nucleotide exchange factor 11 Gene

ARHGEF11 - Rho guanine nucleotide exchange factor 11 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GTRAP48; PDZ-RHOGEF

Gene ID: 9826 | Gene type: protein coding

About ARHGEF11

Cytogenetic location: 1q23.1 Genomic coordinates (GRCh38): 1:156,934,840-157,046,903 (from NCBI)

This gene has 7 transcripts (splice variants), 199 orthologues and 8 paralogues. Ubiquitous expression in testis (RPKM 13.2), brain (RPKM 7.8) and 25 other tissues.

Summary

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin Cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

ARHGEF11 Products(4)

mRNA Protein Name
NM_001377418.1 NP_001364347.1 rho guanine nucleotide exchange factor 11 isoform 3
NM_001377419.1 NP_001364348.1 rho guanine nucleotide exchange factor 11 isoform 4
NM_014784.4 NP_055599.1 rho guanine nucleotide exchange factor 11 isoform 1
NM_198236.3 NP_937879.1 rho guanine nucleotide exchange factor 11 isoform 2

ARHGEF11 Protein Structure

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (49 - 116)

RGS-like

RGS-like: Regulator of G protein signalling-like domain (308 - 486)

RhoGEF

RhoGEF: RhoGEF domain (738 - 922)

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  • 1522 a.a.
Protein Preferred Names Protein Names

rho guanine nucleotide exchange factor 11

Rho guanine exchange factor (GEF) 11

Related Diseases

Diseases Alias
Fetal Macrosomia
Cone-Rod Dystrophy 8

CORD8
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00948 ARHGEF11 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ARHGEF11 MGD MGI:2441869
Rattus norvegicus ARHGEF11 RGD RGD:619705
Macaca mulatta ARHGEF11 VGNC VGNC:69829
Bos taurus ARHGEF11 VGNC VGNC:54878
Felis catus ARHGEF11 VGNC VGNC:59898
Canis familiaris ARHGEF11 VGNC VGNC:38074