2. Gene
  3. LRIG2 - leucine rich repeats and immunoglobulin like domains 2 Gene

LRIG2 - leucine rich repeats and immunoglobulin like domains 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as LIG2; UFS2; LIG-2

Gene ID: 9860 | Gene type: protein coding

About LRIG2

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:113,073,198-113,132,260 (from NCBI)

This gene has 5 transcripts (splice variants), 203 orthologues, 22 paralogues and is associated with 3 phenotypes. Ubiquitous expression in thyroid (RPKM 2.7), ovary (RPKM 2.5) and 25 other tissues.

Summary

This gene encodes a transmembrane protein containing leucine-rich repeats and immunoglobulin-like domains. The encoded protein promotes epidermal growth factor signalling, resulting in increased proliferation. Its expression in the cytoplasm of glioma cells is correlated with poor survival. Mutations in this gene can cause urofacial syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

LRIG2 Products(2)

mRNA Protein Name
NM_001312686.2 NP_001299615.1 leucine-rich repeats and immunoglobulin-like domains protein 2 isoform 2
NM_014813.3 NP_055628.1 leucine-rich repeats and immunoglobulin-like domains protein 2 isoform 1 precursor

LRIG2 Protein Structure

LRR_8

LRR_8: Leucine rich repeat (144 - 192)

LRR_8

LRR_8: Leucine rich repeat (240 - 299)

LRR_6

LRR_6: Leucine Rich repeat (310 - 325)

LRR_8

LRR_8: Leucine rich repeat (336 - 398)

LRR_1

LRR_1: Leucine Rich Repeat (411 - 431)

Ig_2

Ig_2: Immunoglobulin domain (497 - 598)

I-set

I-set: Immunoglobulin I-set domain (602 - 692)

I-set

I-set: Immunoglobulin I-set domain (696 - 783)

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  • 1065 a.a.
Protein Preferred Names Protein Names

leucine-rich repeats and immunoglobulin-like domains protein 2

Related Diseases

Diseases Alias
Urofacial Syndrome 2

UFS2
Urofacial Syndrome 1

Urofacial Syndrome

Ochoa Syndrome

Hydronephrosis With Peculiar Facial Expression

Ufs

Inverted Smile And Occult Neuropathic Bladder

Partial Facial Palsy With Urinary Abnormalities

UFS1

Urofacial Ochoa'S Syndrome

Urofacial Syndrome Type 1

Facial Palsy, Partial, With Urinary Abnormalities

Hydronephrosis-Inverted Smile

Inverted Smile-Neurogenic Bladder

Hydronephrosis-Inverted Smile Syndrome

Inverted Smile-Neurogenic Bladder Syndrome

Partial Facial Palsy Partial With Urinary Abnormalities

Urologic Diseases
Prune Belly Syndrome

Eagle-Barrett Syndrome

Abdominal Muscle Deficiency Syndrome

PBS

Abdominal Muscles, Absence Of, With Urinary Tract Abnormality And Cryptorchidism

Egbrs

Eagle-Barret Syndrome

Urethral Obstruction Sequence

Obrinsky Syndrome

Triad Syndrome

Obrisnksy Syndrome

Euos

Early Urethral Obstruction Sequence

Renal Dysplasia Or Hydronephrosis, Oligohydramnios And Subsequent Lung Hypoplasia Due To Urethral Obstruction

Absence Of Abdominal Muscles With Urinary Tract Abnormality And Cryptorchidism

Abdomen Muscle Deficiency Syndrome

Abdomen Muscular Deficiency Syndrome

Abdominal Muscular Deficiency Syndrome

Abdominal Muscle Aplasia Syndrome
Oligodendroglioma

Oligodendroglial Neoplasm

Oligodendroglial Tumor

Oligodendroglial Tumors

Well Differentiated Oligodendroglioma
Lagophthalmos

Defective Lid Closure

Poor Closure Eyelids
Corpus Callosum, Agenesis Of, With Abnormal Genitalia

Proud Syndrome

Corpus Callosum Agenesis-Abnormal Genitalia Syndrome

Acc With Abnormal Genitalia

Proud-Levine-Carpenter Syndrome

Microcephaly-Corpus Callosum Agenesis-Abnormal Genitalia Syndrome

Corpus Callosum Agenesis With Abnormal Genitalia

New X-Linked Syndrome With Seizures, Acquired Micrencephaly, And Agenesis Of The Corpus Callosum

Proud Levine Carpenter Syndrome

Acc-Abnormal Genitalia Syndrome

Agenesis Of The Corpus Callosum, With Abnormal Genitalia

ACCAG

Micrencephaly-Corpus Callosum Agenesis-Abnormal Genitalia

Congenital Neurologic Anomalies
Vaginal Cancer

Malignant Neoplasm Of Vagina

Vaginal Neoplasms

Malignant Tumor Of Vagina

Malignant Vaginal Tumor

Neoplasm Of Vagina

Vagina Neoplasm

Vaginal Tumor

Vaginal Carcinoma

Vaginal Malignant Epithelial Tumor

Vaginal Neoplasm

Malignant Vaginal Neoplasm

Vagina Carcinoma

Vaginal Neoplasia

Cancer Of Vagina

Malignant Tumour Of Vagina

Carcinoma Of Vagina

Primary Malignant Neoplasm Of Vagina

Vagina Wall Cancer

Vaginal Wall Cancer
Neurogenic Bladder

Neurogenic Dysfunction Of The Urinary Bladder

Neurogenic Urinary Bladder Disorder

Neuropathic Bladder

Bladder Neurogenic

Urinary Bladder, Neurogenic

Neurogenic Urinary Bladder
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 1

Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome

Berdon Syndrome

MMIHS

Megacystis Microcolon Intestinal Hypoperistalsis Syndrome

Megacystis, Microcolon, Hypoperistalsis Syndrome

Visceral Myopathy

Mmih Syndrome

Megacystis-Microcolon-Intestinal Hypoperistalsis-Hydronephrosis Syndrome

MMIHS1

Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome, Mmih

Mmhs
Vesicoureteral Reflux

Vesico-Ureteral Reflux
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07788 LRIG2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus LRIG2 RGD RGD:1309554
Felis catus LRIG2 VGNC VGNC:63281
Mus musculus LRIG2 MGD MGI:2443718
Macaca mulatta LRIG2 VGNC VGNC:74323
Bos taurus LRIG2 VGNC VGNC:30983
Canis familiaris LRIG2 VGNC VGNC:42768