THRAP3 - thyroid hormone receptor associated protein 3 Gene

Homo sapiens

Also known as BCLAF2; TRAP150

Gene ID: 9967 | Gene type: protein coding

About THRAP3

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:36,207,637-36,305,357 (from NCBI)

This gene has 4 transcripts (splice variants), 282 orthologues, 2 paralogues and is associated with 70 phenotypes. Ubiquitous expression in lymph node (RPKM 27.3), thyroid (RPKM 26.7) and 25 other tissues.

Summary

Enables phosphoprotein binding activity; Thyroid Hormone Receptor binding activity; and transcription coactivator activity. Involved in nuclear-transcribed mRNA catabolic process; positive regulation of circadian rhythm; and regulation of RNA metabolic process. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nuclear speck. Part of mediator complex. Colocalizes with exon-exon junction complex. [provided by Alliance of Genome Resources, Apr 2022]

THRAP3 Products(3)

mRNA	Protein	Name
NM_001321471.2	NP_001308400.1	thyroid hormone receptor-associated protein 3 isoform 1
NM_001321473.2	NP_001308402.1	thyroid hormone receptor-associated protein 3 isoform 2
NM_005119.4	NP_005110.2	thyroid hormone receptor-associated protein 3 isoform 1

THRAP3 Protein Structure

THRAP3_BCLAF1

0
200
400
600
800
955 a.a.

Protein Preferred Names

Protein Names

thyroid hormone receptor-associated protein 3

BCLAF1 and THRAP3 family member 2

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder, Autosomal Dominant 2

MRD2	Autosomal Dominant Non-Syndromic Intellectual Disability 2
Autosomal Dominant Intellectual Developmental Disorder 2	Mental Retardation, Autosomal Dominant 2

Telangiectatic Osteogenic Sarcoma

Telangiectatic Osteosarcoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14500	THRAP3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	THRAP3	VGNC	VGNC:100158
Canis familiaris	THRAP3	VGNC	VGNC:47354
Rattus norvegicus	THRAP3	RGD	RGD:1306129
Felis catus	THRAP3	VGNC	VGNC:66173
Bos taurus	THRAP3	VGNC	VGNC:35846
Mus musculus	THRAP3	MGD	MGI:2442637

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