2. Gene
  3. Kdm1a - lysine (K)-specific demethylase 1A Gene

Kdm1a - lysine (K)-specific demethylase 1A Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Aof2; Kdm1; Lsd1; mKIAA0601; D4Ertd478e; 1810043O07Rik

Gene ID: 99982 | Gene type: protein coding

About Kdm1a

Chromosome 4: 136,277,851-136,330,034 reverse strand.GRCm39:CM000997.3

This gene has 9 transcripts (splice variants), 215 orthologues, 9 paralogues and is associated with 39 phenotypes. Ubiquitous expression in CNS E14 (RPKM 42.5), whole brain E14.5 (RPKM 4.5) and 28 other tissues.

Summary

Enables several functions, including DNA-binding transcription factor binding activity; histone H3-di/monomethyl-lysine-4 FAD-dependent demethylase activity; and promoter-specific chromatin binding activity. Involved in several processes, including negative regulation of macromolecule metabolic process; positive regulation of cell population proliferation; and regulation of myeloid cell differentiation. Acts upstream of or within histone H3-K4 demethylation; nervous system development; and positive regulation of transcription by RNA polymerase II. Located in chromatin and nucleus. Is expressed in several structures, including brain; inner cell mass; reproductive system; retina; and urinary system. Orthologous to human KDM1A (lysine demethylase 1A). [provided by Alliance of Genome Resources, Apr 2022]

Kdm1a Products(3)

mRNA Protein Name
NM_001347221.1 NP_001334150.1 lysine-specific histone demethylase 1A isoform 1
NM_001356567.1 NP_001343496.1 lysine-specific histone demethylase 1A isoform 3
NM_133872.2 NP_598633.2 lysine-specific histone demethylase 1A isoform 2

Kdm1a Protein Structure

PHA03378

PHA03378: cl33729 (38 - 98)

PLN02328

PLN02328: cl33466 (203 - 845)

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  • 873 a.a.
Protein Preferred Names Protein Names

lysine-specific histone demethylase 1A

BRAF35-HDAC complex protein BHC110

amine oxidase (flavin containing) domain 2

flavin-containing amine oxidase domain-containing protein 2

lysine (K)-specific demethylase 1

lysine-specific histone demethylase 1

Related Agents

Clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-18632 GSK2879552 Inhibitor 99.75% Phase 2
HY-103713 Seclidemstat Inhibitor 99.77% Phase 2
HY-18632A GSK2879552 dihydrochloride Inhibitor 99.52% Phase 2
HY-12782T Iadademstat dihydrochloride Inhibitor 99.83% Phase 1
HY-138830 TAK-418 Inhibitor 98.64% Phase 1
Pre-clinical Phase
Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-103713A Seclidemstat mesylate Inhibitor 99.86% Unkown
HY-19612B DDP-38003 trihydrochloride Inhibitor / Unkown
HY-19612A DDP-38003 dihydrochloride Inhibitor 98.22% Unkown
HY-109117 Iadademstat Inhibitor / Unkown
HY-112304 NCD38 TFA Inhibitor / Unkown
HY-112304A (1R,2S)-NCD38 TFA Inhibitor / Unkown
HY-143238 FY-56 Inhibitor / Unkown
HY-RS07205 KDM1A Human Pre-designed siRNA Set A / Unkown
HY-RS07206 Kdm1a Mouse Pre-designed siRNA Set A / Unkown
HY-RS07207 Kdm1a Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kdm1a NCBI NCBI:23028