2. Apoptosis
  3. Apoptosis
  4. (Gly14)-Humanin (human)

(Gly14)-Humanin (human)  (Synonyms: 14-Glycine-Humanin (human))

Cat. No.: HY-P3993
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(Gly14)-Humanin (human) (14-Glycine-Humanin (human)) is an analog of Humanin in which the 14th amino acid serine was replaced with glycine (Gly). (Gly14)-Humanin (human) has anti-apoptotic and neuroprotective functions.

For research use only. We do not sell to patients.

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(Gly14)-Humanin (human) Chemical Structure

(Gly14)-Humanin (human) Chemical Structure

CAS No. : 330936-70-4

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(Gly14)-Humanin (human) Related Antibodies

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Description

(Gly14)-Humanin (human) (14-Glycine-Humanin (human)) is an analog of Humanin in which the 14th amino acid serine was replaced with glycine (Gly). (Gly14)-Humanin (human) has anti-apoptotic and neuroprotective functions[1][2].

In Vitro

(Gly14)-Humanin (human) (0.1-10 μM; 72 hours) significantly increases cell viability, reduced nuclear fluorescence of HUVECs, the levels of cleaved PARP, ROS formation and the ratio of bax/bcl-2 compared with treatment with high glucose (HG) for 72h. And reduces mRNA level of bax and increases mRNA level of bcl-2[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(Gly14)-Humanin (human) Related Antibodies

Cell Viability Assay[1]

Cell Line: Human umbilical vein endothelial cells (HUVECs)
Concentration: 100 nM, 1 μM and 10 μM
Incubation Time: Pretreatment 3 hours and then treated with 72 hours
Result: Significantly increased cell viability.

Western Blot Analysis[1]

Cell Line: Human umbilical vein endothelial cells (HUVECs)
Concentration: 1 μM
Incubation Time: Pretreatment 3 hours and then treated with 72 hours
Result: Reduced the ratio of bax/bcl-2.
In Vivo

(Gly14)-Humanin (human) (0.1 μg/5 μL; i.c.v.; once) decreases cells with plasmalemma permeability in the injured cortex and hippocampus, reduces brain lesion volume, improves motor performance and ameliorates performance in the Morris water maze test[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male CD-1 mice (25-30 g; 10-12-week-old) bearing traumatic brain injury (TBI)[2]
Dosage: 0.1 μg/5 μL
Administration: Intracerebroventricularly (i.c.v.); once
Result: Decreased cells with plasmalemma permeability in the injured cortex and hippocampus, reduced brain lesion volume, improved motor performance.
Molecular Weight

2657.21

Formula

C118H202N34O31S2
CAS No.
Sequence Shortening

MAPRGFSCLLLLTGEIDLPVKRRA
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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(Gly14)-Humanin (human) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Gly14)-Humanin (human)330936-70-414-Glycine-Humanin (human)Apoptosisbaxbcl-2PARPROSanti-apoptoticneuroprotectiveInhibitorinhibitorinhibit

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