2. Metabolic Enzyme/Protease
  3. Cathepsin MMP
  4. Hepcidin-1 (mouse) (TFA)

Hepcidin-1 (mouse) TFA is an endogenous peptide hormone involved in the regulation of iron homeostasis. Hepcidin-1 (mouse) TFA upregulates mRNA levels of TRAP, cathepsin K, and MMP-9 and increases TRAP-5b protein secretion. Hepcidin-1 (mouse) TFA downregulates the level of FPN1 protein and increases intracellular iron. Hepcidin-1 (mouse) TFA facilitates osteoclast differentiation.

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Hepcidin-1 (mouse) (TFA) Chemical Structure

Hepcidin-1 (mouse) (TFA) Chemical Structure

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Based on 1 publication(s) in Google Scholar

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Hepcidin-1 (mouse) (TFA) Related Antibodies

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Description

Hepcidin-1 (mouse) TFA is an endogenous peptide hormone involved in the regulation of iron homeostasis. Hepcidin-1 (mouse) TFA upregulates mRNA levels of TRAP, cathepsin K, and MMP-9 and increases TRAP-5b protein secretion. Hepcidin-1 (mouse) TFA downregulates the level of FPN1 protein and increases intracellular iron. Hepcidin-1 (mouse) TFA facilitates osteoclast differentiation[1].

IC50 & Target[1]

MMP-9

 

cathepsin K

 

In Vitro

Hepcidin-1 (mouse) TFA (200-800 nM, 4 days) facilitates RANKL (50 ng/mL)-induced differentiation of raw264.7 cells[1].
Hepcidin-1 (mouse) TFA (0-800 nM, 4 days) up-regulates the expression of TRAP, CTK, and MMP-9 mRNA[1].
Hepcidin-1 (mouse) TFA (0-800 nM, 20 h) increases the Level of Trap-5b protein and decreased Ferroportin 1 (FPN1) protein in RAW264.7 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Hepcidin-1 (mouse) (TFA) Related Antibodies

Western Blot Analysis[1]

Cell Line: RAW264.7 cells
Concentration: 0, 200, 400, or 800 nM
Incubation Time: 20 h
Result: Decreased Ferroportin 1 (FPN1) protein.

RT-PCR[1]

Cell Line: RAW264.7 cells
Concentration: 0, 200, 400, or 800 nM
Incubation Time: 4 days
Result: Increased the gene expression of TRAP, CTK, and MMP-9 in a dose-dependent manner.
Molecular Weight

2754.24 (free base)

Formula

C111H169N31O35S8.xC2HF3O2
Appearance

Solid

Color

White to off-white

Sequence

Asp-Thr-Asn-Phe-Pro-Ile-Cys-Ile-Phe-Cys-Cys-Lys-Cys-Cys-Asn-Asn-Ser-Gln-Cys-Gly-Ile-Cys-Cys-Lys-Thr (Disulfide bridge: Cys7-Cys23,Cys10-Cys22,Cys11-Cys19,Cys13-Cys14)
Sequence Shortening

DTNFPICIFCCKCCNNSQCGICCKT (Disulfide bridge: Cys7-Cys23,Cys10-Cys22,Cys11-Cys19,Cys13-Cys14)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (Need ultrasonic)

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This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 98.94%

COA (275 KB) LCMS (92 KB)

Handling Instructions (2659 KB)
References
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Hepcidin-1 (mouse) (TFA) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hepcidin-1 (mouse) (TFA)CathepsinMMPMatrix metalloproteinasespolypeptidepeptide screeningosteoclastiron homeostasisInhibitorinhibitorinhibit

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