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  4. HG106

HG106 is a potent SLC7A11 inhibitor. HG106 markedly decreased cystine uptake and intracellular glutathione biosynthesis. HG106 can be used for the research of KRAS-mutant lung adenocarcinoma.

For research use only. We do not sell to patients.

HG106 Chemical Structure

HG106 Chemical Structure

CAS No. : 928712-10-1

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5 mg USD 180 In-stock
10 mg USD 290 In-stock
25 mg USD 550 In-stock
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Based on 1 publication(s) in Google Scholar

HG106 Related Antibodies

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Description

HG106 is a potent SLC7A11 inhibitor. HG106 markedly decreased cystine uptake and intracellular glutathione biosynthesis. HG106 can be used for the research of KRAS-mutant lung adenocarcinoma[1].

Molecular Weight

316.74

Formula

C15H13ClN4O2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(NC1=CC2=NN(C3=CC=C(OC)C=C3)N=C2C=C1)CCl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (394.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1572 mL 15.7858 mL 31.5716 mL
5 mM 0.6314 mL 3.1572 mL 6.3143 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.95%

COA (244 KB) HNMR (139 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1572 mL 15.7858 mL 31.5716 mL 78.9291 mL
5 mM 0.6314 mL 3.1572 mL 6.3143 mL 15.7858 mL
10 mM 0.3157 mL 1.5786 mL 3.1572 mL 7.8929 mL
15 mM 0.2105 mL 1.0524 mL 2.1048 mL 5.2619 mL
20 mM 0.1579 mL 0.7893 mL 1.5786 mL 3.9465 mL
25 mM 0.1263 mL 0.6314 mL 1.2629 mL 3.1572 mL
30 mM 0.1052 mL 0.5262 mL 1.0524 mL 2.6310 mL
40 mM 0.0789 mL 0.3946 mL 0.7893 mL 1.9732 mL
50 mM 0.0631 mL 0.3157 mL 0.6314 mL 1.5786 mL
60 mM 0.0526 mL 0.2631 mL 0.5262 mL 1.3155 mL
80 mM 0.0395 mL 0.1973 mL 0.3946 mL 0.9866 mL
100 mM 0.0316 mL 0.1579 mL 0.3157 mL 0.7893 mL
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HG106 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HG106928712-10-1HG 106HG-106OthersSLC7A11cysteineglutathione biosynthesisKRAS-mutant lung adenocarcinomaInhibitorinhibitorinhibit

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