HIV-1 inhibitor-47

Cat. No.: HY-148042 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

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HIV-1 inhibitor-47 is an inhibitor of HIV-1, and inhibits vif-dependent degradation of human APOBEC3G, with an IC₅₀ value of 14.33 μM. HIV-1 inhibitor-47 also involves in derivatives of 1-(2-pyrimidinyl)piperazine synthesis, with potential antianxiety, antidepressant, and antipsychotic effect.

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HIV-1 inhibitor-47 Chemical Structure

CAS No. : 137448-39-6

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5 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 130	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description	HIV-1 inhibitor-47 is an inhibitor of HIV-1, and inhibits vif-dependent degradation of human APOBEC3G, with an IC₅₀ value of 14.33 μM. HIV-1 inhibitor-47 also involves in derivatives of 1-(2-pyrimidinyl)piperazine synthesis, with potential antianxiety, antidepressant, and antipsychotic effect^[1]^[2]^[3].
IC₅₀ & Target	HIV (Vif-dependent degradation of human APOBEC3G)^[1]
In Vitro	APOBEC3G (A3G), a host cytidine deaminase that can block HIV-1 replication and shows antiviral activity. However HIV-1 develops the ability to hijack the cellular ubiquitin/proteasome degradation pathway^[1]. HIV-1 inhibitor-47 targets APOBEC3G-apolipoprotein B mRNA editing enzyme catalytic subunit 3G (human), and works on the HIV-1 Vif-APOBEC3G interaction^[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. HIV-1 inhibitor-47 Related Antibodies
Molecular Weight	242.28
Formula	C₁₂H₁₄N₆
CAS No.	137448-39-6
Appearance	Solid
Color	White to off-white
SMILES	C1(N2CCN(CC2)C3=NC=CC=N3)=NC=CN=C1
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Purity & Documentation	Purity: ≥98.0% Select Batch: Data Sheet (269 KB) SDS (393 KB) COA (248 KB) HNMR (148 KB) Handling Instructions (2659 KB)
References	[1]. Iwatani Y, et al. HIV-1 Vif-mediated ubiquitination/degradation of APOBEC3G involves four critical lysine residues in its C-terminal domain. Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19539-44. [Content Brief] [2]. Becker Irwin. Preparation of derivatives of 1-(2-pyrimidinyl)piperazine as potential antianxiety, antidepressant, and antipsychotic agents. Journal of Heterocyclic Chemistry. 2008;45(4):1005-1022. [3]. Pubchem: 2-(4-(Pyrazin-2-yl)piperazin-1-yl)pyrimidine-BioAssay Results.