2. PROTAC
  3. PROTAC Linkers
  4. HO-PEG10-CH2COOH

HO-PEG10-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

HO-PEG10-CH2COOH Chemical Structure

HO-PEG10-CH2COOH Chemical Structure

CAS No. : 2250056-53-0

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HO-PEG10-CH2COOH Related Antibodies

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Description

HO-PEG10-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HO-PEG10-CH2COOH Related Antibodies
Molecular Weight

516.58

Formula

C22H44O13
CAS No.
Appearance

Oil

Color

Colorless to light yellow

SMILES

O=C(O)COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (193.58 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9358 mL 9.6790 mL 19.3581 mL
5 mM 0.3872 mL 1.9358 mL 3.8716 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

=
Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9358 mL 9.6790 mL 19.3581 mL 48.3952 mL
5 mM 0.3872 mL 1.9358 mL 3.8716 mL 9.6790 mL
10 mM 0.1936 mL 0.9679 mL 1.9358 mL 4.8395 mL
15 mM 0.1291 mL 0.6453 mL 1.2905 mL 3.2263 mL
20 mM 0.0968 mL 0.4840 mL 0.9679 mL 2.4198 mL
25 mM 0.0774 mL 0.3872 mL 0.7743 mL 1.9358 mL
30 mM 0.0645 mL 0.3226 mL 0.6453 mL 1.6132 mL
40 mM 0.0484 mL 0.2420 mL 0.4840 mL 1.2099 mL
50 mM 0.0387 mL 0.1936 mL 0.3872 mL 0.9679 mL
60 mM 0.0323 mL 0.1613 mL 0.3226 mL 0.8066 mL
80 mM 0.0242 mL 0.1210 mL 0.2420 mL 0.6049 mL
100 mM 0.0194 mL 0.0968 mL 0.1936 mL 0.4840 mL
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HO-PEG10-CH2COOH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HO-PEG10-CH2COOH2250056-53-0PROTAC LinkersInhibitorinhibitorinhibit

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