IL17A-IN-1

Cat. No.: HY-158159: FAQs
Data Sheet Handling Instructions

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IL17A-IN-1 (compound 72) is an orally active Interleukin 17A inhibitor. IL17A-IN-1 can be used in the study of inflammatory and autoimmune diseases (plaque psoriasis, psoriatic arthritis, and ankylosing spondylitis, etc.), as well as cancer.

For research use only. We do not sell to patients.

IL17A-IN-1 Chemical Structure

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Description

In Vitro

IL17A-IN-1 inhibits Hela cells with an IC₅₀ value of 0.005 µM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

IL17A-IN-1 (10 mg/kg; p.o.; single dose) inhibits plasma CXCL1 secretion in hIL17A-induced mouse (IL17 receptor-containing mouse) CXCL1 PD model^[1]. (Subcutaneous injection of recombinant human IL17A into mice induces plasma CXCL1 secretion).

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6 mice (hIL17A-induced mouse CXCL1 PD model)^[1].
Dosage:	10 mg/kg
Administration:	Oral administration; single dose
Result:	Inhibited 53% of CXCL1 secretion in hIL17A-induced mouse CXCL1 PD model.

Animal Model:

Male Sprague-Dawley rats; 360-460 g^[1].

Dosage:

0.3 mg/kg

Administration:

Intravenous injection; single dose

Result:

1.19 Pharmacokinetic Parameters of IL17A-IN-1 in male Sprague-Dawley rats^[1].

	IV (0.3 mg/kg)
V_ss (L/kg)	5.0
t_1/2 (h)	3.6
CLp/CLp,u (L/h/kg)	1.1/6.1

Molecular Weight

612.55

Formula

C₃₀H₃₅Cl₂N₇O₃

SMILES

CN1CCC(N2CC3=NC([C@H](C)NC([C@@]4(NC(C5=CC(Cl)=C(Cl)N5)=O)C[C@H](OC4)C6=CC=CC=C6)=O)=NC=C3C2)CC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ramos AL, et al. Discovery of Small Molecule Interleukin 17A Inhibitors with Novel Binding Mode and Stoichiometry: Optimization of DNA-Encoded Chemical Library Hits to In Vivo Active Compounds. J Med Chem. 2024 Apr 4. [Content Brief]

IL17A-IN-1 Related Classifications

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Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IL17A-IN-1Interleukin RelatedILHelaplaque psoriasispsoriatic arthritisankylosing spondylitiscancertumorautoimmuneinflammationInhibitorinhibitorinhibit

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