2. Isotope-Labeled Compounds
  3. Internal Standard for Clinical Mass Spectrometry
  4. Therapeutic Drug Monitoring: TDM
  5. Hormones

Hormones

A) Hormones

Hormones (104):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-18569S
    3-Indoleacetic acid-d5 76937-78-5 99.84%
    3-Indoleacetic acid-d5 is the deuterium labeled 3-Indoleacetic acid. 3-Indoleacetic acid-d5 can be used as internal standard for assay of IAA releases by alkaline hydrolysis of ester and amide conjugates[1].
    3-Indoleacetic acid-d<sub>5</sub>
  • HY-N0322S
    Cholesterol-d7 83199-47-7 ≥98.0%
    Cholesterol-d7 is the deuterium labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins. Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist.
    Cholesterol-d<sub>7</sub>
  • HY-B0075S
    Melatonin-d4 66521-38-8
    Melatonin-d4 is deuterium labeled Melatonin. Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Antioxidative and anti-inflammatory properties[1][2][3]. Melatonin is a selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation[4].
    Melatonin-d<sub>4</sub>
  • HY-N7142S
    DL-Norepinephrine-d6 hydrochloride 1219803-04-9 99.88%
    DL-Norepinephrine-d6 (hydrochloride) is the deuterium labeled DL-Norepinephrine hydrochloride. DL-Norepinephrine hydrochloride is a synthetic phenylethylamine that mimics the sympathomimetic actions of the endogenous norepinephrine．DL-Norepinephrine hydrochloride is a neurotransmitter targets α1 and β1 adrenoceptors, has an increasing effect on subendocardial oxygen tension[1].
    DL-Norepinephrine-d<sub>6</sub> hydrochloride
  • HY-B0141S
    Estradiol-d3 79037-37-9 98.60%
    Estradiol-d3 is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.
    Estradiol-d<sub>3</sub>
  • HY-113263S
    17a-Hydroxypregnenolone-d3 105078-92-0 ≥99.0%
    17a-Hydroxypregnenolone-d3 is the deuterium labeled 17a-Hydroxypregnenolone. 17a-Hydroxypregnenolone is a pregnane steroid. 17a-Hydroxypregnenolone is a prohormone in the formation of dehydroepiandrosterone (DHEA).
    17a-Hydroxypregnenolone-d<sub>3</sub>
  • HY-14648S
    Dexamethasone-d5 358731-91-6 99.86%
    Dexamethasone-d5 is the deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses[1][2].
    Dexamethasone-d<sub>5</sub>
  • HY-B0412S2
    Estriol-d3 79037-36-8
    Estriol-d3 is the deuterium labeled Estriol. Estriol is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells.
    Estriol-d<sub>3</sub>
  • HY-132421S
    (±)-Equol-d4 1216469-13-4 99.79%
    (±)-Equol-d4 is the deuterium labeled (±)-Equol[1].
    (±)-Equol-d<sub>4</sub>
  • HY-108568S
    15-Deoxy-Δ-12,14-prostaglandin J2-d4 1542166-82-4 98.10%
    15-Deoxy-Δ-12,14-prostaglandin J2-d4 is the deuterium labeled 15-Deoxy-Δ-12,14-prostaglandin J2. 15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. 15-Deoxy-Δ-12,14-prostaglandin J2 is a selective PPARγ (EC50 of 2 µM) and a covalent PPARδ agonist. 15-Deoxy-Δ-12,14-prostaglandin J2 promotes efficient differentiation of C3H10T1/2 fibroblasts to adipocytes with an EC50 of 7 μM[1][2].
    15-Deoxy-Δ-12,14-prostaglandin J2-d<sub>4</sub>
  • HY-18569S2
    3-Indoleacetic acid-2,2-d2 24420-86-8 98.06%
    3-Indoleacetic acid-2,2-d2 is the deuterium labeled 3-Indoleacetic acid. 3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division.
    3-Indoleacetic acid-2,2-d<sub>2</sub>
  • HY-B0234S1
    Estrone-d2 350820-16-5 99.78%
    Estrone-d2 is the deuterium labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells[1][2].
    Estrone-d<sub>2</sub>
  • HY-103638S
    3-Methoxytyramine-d4 hydrochloride 1216788-76-9 ≥99.0%
    3-Methoxytyramine-d4 (hydrochloride) is the deuterium labeled 3-Methoxytyramine hydrochloride. 3-Methoxytyramine hydrochloride is an inactive metabolite of dopamine which can activate trace amine associated receptor 1 (TAAR1)[1][2].
    3-Methoxytyramine-d<sub>4</sub> hydrochloride
  • HY-113031S
    16α-Hydroxydehydroepiandrosterone-d5
    16α-Hydroxydehydroepiandrosterone-d5 (16α-Hydroxy-DHEA-d5) is the deuterium labeled 16α-Hydroxydehydroepiandrosterone[1].
    16α-Hydroxydehydroepiandrosterone-d<sub>5</sub>
  • HY-101952S
    Prostaglandin E2-d4 34210-10-1 ≥99.0%
    Prostaglandin E2-d4 is the deuterium labeled Prostaglandin E2. Prostaglandin E2 (PGE2) is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation[1][2].
    Prostaglandin E2-d<sub>4</sub>
  • HY-B0216S
    Ethynyl Estradiol-d4 350820-06-3
    Ethynyl Estradiol-d4 is the deuterium labeled Ethynyl Estradiol. Ethynyl Estradiol (17α-Ethynylestradiol;Ethynylestradiol) is an orally bio-active estrogen used in almost all modern formulations of combined oral contraceptive pills. Ethynyl Estradiol-d4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Ethynyl Estradiol-d<sub>4</sub>
  • HY-B0561S
    Spironolactone-d7 99.96%
    Spironolactone-d7 is the deuterium labeled Spironolactone. Spironolactone (SC9420) is an orally active aldosterone mineralocorticoid receptor antagonist with an IC50 of 24 nM. Spironolactone is also a potent antagonist of androgen receptor with an IC50 of 77 nM. Spironolactone promotes autophagy in podocytes[1][2][3].
    Spironolactone-d<sub>7</sub>
  • HY-B0561S1
    Spironolactone-d3 99.82%
    Spironolactone-d3 is the deuterium labeled Spironolactone. Spironolactone (SC9420) is an orally active aldosterone mineralocorticoid receptor antagonist with an IC50 of 24 nM. Spironolactone is also a potent antagonist of androgen receptor with an IC50 of 77 nM. Spironolactone promotes autophagy in podocytes[1][2][3].
    Spironolactone-d<sub>3</sub>
  • HY-15731S
    Estetrol-d4
    Estetrol-d4 is the deuterium labeled Estetrol. Estetrol, a natural estrogen synthesized exclusively during pregnancy by the human fetal liver, is a selective nuclear estrogen receptor modulator. Estetrol exerts estrogenic actions on the endometrium or the central nervous system but presents antagonistic effects on the breast[1][2].
    Estetrol-d<sub>4</sub>
  • HY-111614S2
    Melengestrol acetate-d3 ≥99.0%
    Melengestrol acetate-d3 is the deuterium labeled Melengestrol acetate. Melengestrol acetate is a progesterone derivative, acts as an orally active corticosteroid hormone to promote endometrial proliferation, pregnancy maintenance, and delay of menstrual activity[1]. Melengestrol Acetate is used as a contraceptive agent for growth promoting effects and suppression of estrus in animals. Melengestrol acetate inhibits both the androgen-dependent and -independent prostatic tumors in vivo and can be used for cancer research[2].
    Melengestrol acetate-d<sub>3</sub>