2. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. JAK
  4. JAK1-IN-12

JAK1-IN-12 is a selective inhibitor of JAK1, with IC50 of 0.0246 μM. And IC50s of 0.423 μM, 0.410 μM and 1.12 μM for JAK2, JAK3 and TYK2. JAK1-IN-12 promotes hair growth in mice. JAK1-IN-12 can be used for research of immune and inflammatory diseases.

For research use only. We do not sell to patients.

JAK1-IN-12 Chemical Structure

JAK1-IN-12 Chemical Structure

CAS No. : 2945204-95-3

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JAK1-IN-12 Related Antibodies

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Description

JAK1-IN-12 is a selective inhibitor of JAK1, with IC50 of 0.0246 μM. And IC50s of 0.423 μM, 0.410 μM and 1.12 μM for JAK2, JAK3 and TYK2. JAK1-IN-12 promotes hair growth in mice. JAK1-IN-12 can be used for research of immune and inflammatory diseases[1].

IC50 & Target[1]

JAK1

0.0246 μM (IC50)

JAK2

0.423 μM (IC50)

JAK3

0.410 μM (IC50)

Tyk2

1.12 μM (IC50)

In Vitro

HDAC-IN-57 (Compound 12b) inhibits JAK1 and JAK2 activity in Ba/F3-TEL-JAK1 cell lines, with IC50 of 0.110 μM and 6.105 μM[1].
HDAC-IN-57 (Compound 12b) (1 μM) showed strong interaction with JAK1, JAK3, PKD2, HPK1, AurB in vitro panel assay[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JAK1-IN-12 Related Antibodies
In Vivo

JAK1-IN-12 (Compound 12b) (2%, in 10% DMSO solution, daily to half of the shaved area for 1 month) promotes hair growth in the shaved area of the dorsal back of 8-week-old C57/B6 mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57/B6 mice[1]
Dosage: 2% in 10% DMSO solution
Administration: External use; applied daily for 1 month
Result: Promoted skin darkening within 9 days and new hair growth within 13 days in shaved area of the dorsal back of C57/B6 mice
Molecular Weight

349.43

Formula

C20H23N5O
CAS No.
SMILES

O[C@]12C[C@@H](C[C@H]3C2)[C@H](NC4=C(C=CN5)C5=NC=C4C6=CNN=C6)[C@@H](C3)C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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In Vivo:

The following protocol is derived from the literature and is for reference only. It is recommended to first try a small sample.

  • Protocol 1

    2% JAK1-IN-12 在 10% DMSO 溶液中，具体而言，将 200 mg 干粉溶解在 1 mL DMSO 中，然后在 10 mL 水中稀释。

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Purity & Documentation
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JAK1-IN-12 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JAK1-IN-122945204-95-3JAKJanus kinaseJAK1 inhibitorBa/F3hair growthimmuneinflammatoryInhibitorinhibitorinhibit

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