2. MAPK/ERK Pathway
  3. JNK
  4. JNK-IN-13

JNK-IN-13 (compound 1) is a potent and selective JNK inhibitor with IC50s of 290 nM and 500 nM for JNK3 and JNK2, respectively.

For research use only. We do not sell to patients.

JNK-IN-13 Chemical Structure

JNK-IN-13 Chemical Structure

CAS No. : 345986-38-1

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25 mg USD 65 In-stock
50 mg USD 105 In-stock
100 mg USD 165 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

JNK-IN-13 (compound 1) is a potent and selective JNK inhibitor with IC50s of 290 nM and 500 nM for JNK3 and JNK2, respectively[1].

IC50 & Target[1]

JNK2

500 nM (IC50)

JNK3

290 nM (IC50)

Molecular Weight

286.74

Formula

C13H7ClN4S
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

ClC1=NC(C(C2=NC3=CC=CC=C3S2)C#N)=CC=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 31 mg/mL (108.11 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4875 mL 17.4374 mL 34.8748 mL
5 mM 0.6975 mL 3.4875 mL 6.9750 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4875 mL 17.4374 mL 34.8748 mL 87.1870 mL
5 mM 0.6975 mL 3.4875 mL 6.9750 mL 17.4374 mL
10 mM 0.3487 mL 1.7437 mL 3.4875 mL 8.7187 mL
15 mM 0.2325 mL 1.1625 mL 2.3250 mL 5.8125 mL
20 mM 0.1744 mL 0.8719 mL 1.7437 mL 4.3594 mL
25 mM 0.1395 mL 0.6975 mL 1.3950 mL 3.4875 mL
30 mM 0.1162 mL 0.5812 mL 1.1625 mL 2.9062 mL
40 mM 0.0872 mL 0.4359 mL 0.8719 mL 2.1797 mL
50 mM 0.0697 mL 0.3487 mL 0.6975 mL 1.7437 mL
60 mM 0.0581 mL 0.2906 mL 0.5812 mL 1.4531 mL
80 mM 0.0436 mL 0.2180 mL 0.4359 mL 1.0898 mL
100 mM 0.0349 mL 0.1744 mL 0.3487 mL 0.8719 mL
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JNK-IN-13 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNK-IN-13345986-38-1JNKc-Jun N-terminal kinaseJNK3JNK2Inhibitorinhibitorinhibit

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