2. PROTAC GPCR/G Protein MAPK/ERK Pathway
  3. PROTACs Ras
  4. Setidegrasib

Setidegrasib  (Synonyms: KRAS G12D inhibitor 17)

Cat. No.: HY-148273 Purity: 99.65%
COA Handling Instructions

Molarity Calculator

Setidegrasib (example 8) is a quinazoline-linked (4R)-4-hydroxy-L-prolinamide compound, inducing degradation of G12D-mutation KRAS protein. Setidegrasib is a PROTAC.

For research use only. We do not sell to patients.

Setidegrasib Chemical Structure

Setidegrasib Chemical Structure

CAS No. : 2821793-99-9

Size Price Stock Quantity
1 mg USD 1250 In-stock
5 mg USD 2503 In-stock
10 mg USD 4008 In-stock
25 mg USD 8015 In-stock
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Setidegrasib Related Antibodies

Top Publications Citing Use of Products

View All PROTACs Isoform Specific Products:

View All Isoforms

View All Ras Isoform Specific Products:

View All Isoforms

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Setidegrasib (example 8) is a quinazoline-linked (4R)-4-hydroxy-L-prolinamide compound, inducing degradation of G12D-mutation KRAS protein. Setidegrasib is a PROTAC[1].

IC50 & Target

KRAS(G12D)

 

Molecular Weight

1117.30

Formula

C60H65FN12O7S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(C(C(C(C1CC1)=CC(C(N2[C@@](CN3)([H])C[C@@]3([H])C2)=N4)=C5N=C4OC6CCOCC6)=C5OCC7=CC=C(C(N=N8)=CN8[C@@H](C(C)C)C(N(C[C@@H]9O)[C@@H](C9)C(N[C@H](C%10=CC=C(C(SC=N%11)=C%11C)C=C%10)CO)=O)=O)C=C7)=C(C=NN%12)C%12=C%13)=C%13F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (111.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8950 mL 4.4751 mL 8.9501 mL
5 mM 0.1790 mL 0.8950 mL 1.7900 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8950 mL 4.4751 mL 8.9501 mL 22.3754 mL
5 mM 0.1790 mL 0.8950 mL 1.7900 mL 4.4751 mL
10 mM 0.0895 mL 0.4475 mL 0.8950 mL 2.2375 mL
15 mM 0.0597 mL 0.2983 mL 0.5967 mL 1.4917 mL
20 mM 0.0448 mL 0.2238 mL 0.4475 mL 1.1188 mL
25 mM 0.0358 mL 0.1790 mL 0.3580 mL 0.8950 mL
30 mM 0.0298 mL 0.1492 mL 0.2983 mL 0.7458 mL
40 mM 0.0224 mL 0.1119 mL 0.2238 mL 0.5594 mL
50 mM 0.0179 mL 0.0895 mL 0.1790 mL 0.4475 mL
60 mM 0.0149 mL 0.0746 mL 0.1492 mL 0.3729 mL
80 mM 0.0112 mL 0.0559 mL 0.1119 mL 0.2797 mL
100 mM 0.0090 mL 0.0448 mL 0.0895 mL 0.2238 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Setidegrasib Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Setidegrasib2821793-99-9KRAS G12D inhibitor 17PROTACsRasquinazoline-linked (4R)-4-hydroxy-L-prolinamide compoundprotein degradationG12D-mutationInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Setidegrasib
Cat. No.:
HY-148273
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.