2. Immunology/Inflammation
  3. Interleukin Related
  4. Lib2-1

Lib2-1, a macrocyclic peptide, is an IL-17C/IL-17RE interaction inhibitor. Lib2-1 can be used for autoimmune and inflammatory diseases research.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Lib2-1 Chemical Structure

Lib2-1 Chemical Structure

CAS No. : 2983116-47-6

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Lib2-1 Related Antibodies

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Description

Lib2-1, a macrocyclic peptide, is an IL-17C/IL-17RE interaction inhibitor. Lib2-1 can be used for autoimmune and inflammatory diseases research[1].

Molecular Weight

1733.90

Formula

C81H108N18O23S
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Ac-Tyr-His-Ile-Tyr-Tyr-Ala-Ser-Leu-Tyr-Gly-Asp-Leu-Gly-Cys-Gly-NH2 (Thioether bond between: Tyr1-Cys15)
Sequence Shortening

Ac-YHIYYASLYGDLGCG-NH2 (Thioether bond between: Tyr1-Cys15)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (57.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5767 mL 2.8837 mL 5.7673 mL
5 mM 0.1153 mL 0.5767 mL 1.1535 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.5767 mL 2.8837 mL 5.7673 mL 14.4184 mL
5 mM 0.1153 mL 0.5767 mL 1.1535 mL 2.8837 mL
10 mM 0.0577 mL 0.2884 mL 0.5767 mL 1.4418 mL
15 mM 0.0384 mL 0.1922 mL 0.3845 mL 0.9612 mL
20 mM 0.0288 mL 0.1442 mL 0.2884 mL 0.7209 mL
25 mM 0.0231 mL 0.1153 mL 0.2307 mL 0.5767 mL
30 mM 0.0192 mL 0.0961 mL 0.1922 mL 0.4806 mL
40 mM 0.0144 mL 0.0721 mL 0.1442 mL 0.3605 mL
50 mM 0.0115 mL 0.0577 mL 0.1153 mL 0.2884 mL
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Lib2-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lib2-12983116-47-6Interleukin RelatedILautoimmune and inflammatory diseases IL-17C/IL-17RE interactionmacrocyclic peptideInhibitorinhibitorinhibit

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