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Licostinel  (Synonyms: ACEA-1021)

Cat. No.: HY-117547 Purity: 98.12%
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Licostinel (ACEA-1021) is a glycine receptor antagonist (IC50: 59 nM). Licostinel has neuroprotective activity.

For research use only. We do not sell to patients.

Licostinel Chemical Structure

Licostinel Chemical Structure

CAS No. : 153504-81-5

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10 mg USD 110 In-stock
25 mg USD 225 In-stock
50 mg USD 360 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Licostinel (ACEA-1021) is a glycine receptor antagonist (IC50: 59 nM). Licostinel has neuroprotective activity[1][2][3].

IC50 & Target

59 nM (glycine receptor)[1]
In Vivo
Animal Model: The permanent model of middle cerebral artery occlusion in fisher 344 rats and CD-1 mice.
The transient model of focal ischemia in Wistar and Sprague –Dawley rats [2
Dosage: 5 mg/kg bolus 3.5 mg/kg/h for 6h, 10 mg/kg bolus 7.0 mg/kg/h for 6h
Administration: A single intravenous injection bolus continuous infusion
Result: Decreased infarct size.
Animal Model: Male Sprague-Dawley rats [3]
Dosage: 20, 40, 80 mg/kg for intraperitoneal injection (i.p.) bolus 7 mg/kg/h , 30mins
Administration: Intravenous injection (i.v.) bolus continuous infusion
Result: Reduced the rate of spreading depression and EEG activity in the rat brain in a dose-dependent manner.
Molecular Weight

276.03

Formula

C8H3Cl2N3O4
CAS No.
Appearance

Solid

Color

Light yellow to light brown

SMILES

O=C1NC2=C(NC1=O)C([N+]([O-])=O)=C(C(Cl)=C2)Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (45.28 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6228 mL 18.1140 mL 36.2279 mL
5 mM 0.7246 mL 3.6228 mL 7.2456 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6228 mL 18.1140 mL 36.2279 mL 90.5699 mL
5 mM 0.7246 mL 3.6228 mL 7.2456 mL 18.1140 mL
10 mM 0.3623 mL 1.8114 mL 3.6228 mL 9.0570 mL
15 mM 0.2415 mL 1.2076 mL 2.4152 mL 6.0380 mL
20 mM 0.1811 mL 0.9057 mL 1.8114 mL 4.5285 mL
25 mM 0.1449 mL 0.7246 mL 1.4491 mL 3.6228 mL
30 mM 0.1208 mL 0.6038 mL 1.2076 mL 3.0190 mL
40 mM 0.0906 mL 0.4528 mL 0.9057 mL 2.2642 mL
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Licostinel Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Licostinel153504-81-5ACEA-1021ACEA1021ACEA 1021OthersneuroprotectivestrokeGlyR antagonistInhibitorinhibitorinhibit

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