LM-41

Cat. No.: HY-155309 Purity: 99.82%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

LM-41 is a Flufenamic acid-derived TEAD inhibitor hat strongly reduce the expression of CTGF, Cyr61, Axl and NF2. LM-41 inhibits migration of human MDA-MB-231 breast cancer cells.

For research use only. We do not sell to patients.

LM-41 Chemical Structure

CAS No. : 2996821-30-6

Size	Price	Stock	Quantity
5 mg	USD 222	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 333	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 666	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1000	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1300	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Description

LM-41 is a Flufenamic acid-derived TEAD inhibitor hat strongly reduce the expression of CTGF, Cyr61, Axl and NF2. LM-41 inhibits migration of human MDA-MB-231 breast cancer cells^[1].

Molecular Weight

307.32

Formula

C₁₉H₁₄FNO₂

CAS No.

2996821-30-6

Appearance

Solid

Color

White to off-white

SMILES

OC(C1=CC=C(F)C=C1NC2=CC(C3=CC=CC=C3)=CC=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 140 mg/mL (455.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.2539 mL	16.2697 mL	32.5394 mL
5 mM	0.6508 mL	3.2539 mL	6.5079 mL
10 mM	0.3254 mL	1.6270 mL	3.2539 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.82%

Select Batch:

Data Sheet (269 KB) SDS (0 KB)

COA (249 KB) HNMR (247 KB) RP-HPLC (261 KB) LCMS (112 KB)

Handling Instructions (2659 KB)

References

[1]. Ahmed Fnaiche, et al. Development of LM-41 and AF-2112, two flufenamic acid-derived TEAD inhibitors obtained through the replacement of the trifluoromethyl group by aryl rings. Bioorg Med Chem Lett. 2023 Oct 15:95:129488. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.2539 mL	16.2697 mL	32.5394 mL	81.3484 mL
	5 mM	0.6508 mL	3.2539 mL	6.5079 mL	16.2697 mL
	10 mM	0.3254 mL	1.6270 mL	3.2539 mL	8.1348 mL
	15 mM	0.2169 mL	1.0846 mL	2.1693 mL	5.4232 mL
	20 mM	0.1627 mL	0.8135 mL	1.6270 mL	4.0674 mL
	25 mM	0.1302 mL	0.6508 mL	1.3016 mL	3.2539 mL
	30 mM	0.1085 mL	0.5423 mL	1.0846 mL	2.7116 mL
	40 mM	0.0813 mL	0.4067 mL	0.8135 mL	2.0337 mL
	50 mM	0.0651 mL	0.3254 mL	0.6508 mL	1.6270 mL
	60 mM	0.0542 mL	0.2712 mL	0.5423 mL	1.3558 mL
	80 mM	0.0407 mL	0.2034 mL	0.4067 mL	1.0169 mL
	100 mM	0.0325 mL	0.1627 mL	0.3254 mL	0.8135 mL

LM-41 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LM-412996821-30-6LM41LM 41YAPYes-associated proteinTEAD inhibitorCTGFCyr61AxlNF2migrationInhibitorinhibitorinhibit

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