2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. HDAC Apoptosis
  4. MC2625

MC2625 is a potent pyridine-containing histone deacetylase (HDAC) inhibitor. MC2625 show selective HDAC3 and HDAC6 inhibition with IC50s of 80 nM and 11 nM. MC2625 increases acetyl-H3 and acetyl-tubulin levels and inhibits cancer stem cells (CSCs) growth by apoptosis induction.

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MC2625 Chemical Structure

MC2625 Chemical Structure

CAS No. : 1776116-75-6

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MC2625 Related Antibodies

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Description

MC2625 is a potent pyridine-containing histone deacetylase (HDAC) inhibitor. MC2625 show selective HDAC3 and HDAC6 inhibition with IC50s of 80 nM and 11 nM. MC2625 increases acetyl-H3 and acetyl-tubulin levels and inhibits cancer stem cells (CSCs) growth by apoptosis induction[1][2].

IC50 & Target[1][2]

HDAC3

80 nM (IC50)

HDAC6

11 nM (IC50)

HDAC1

1.42 μM (IC50)

HDAC2

1.77 μM (IC50)

HDAC4

11.7 μM (IC50)

HDAC5

9.37 μM (IC50)

HDAC7

8.77 μM (IC50)

HDAC8

0.61 μM (IC50)

HDAC9

10.6 μM (IC50)

HDAC10

1.8 μM (IC50)

HDAC11

10.2 μM (IC50)

In Vitro

MC2625 (0.5-2 μM; 24-72 h) has potent antiproliferative effect on different sarcoma CSCs (cancer stem cells) after 72 h[1].
MC2625 (0.5-2 μM; 48 h) significantly induces apoptosis of all CSC cultures, with the exception of A204 CSCs[1].
MC2625 (0.5, 2 μM; 24 h) causes a dose-dependent increase of acetyl-histone H3[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MC2625 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: Cancer stem cells (HOS, MG-63, RD, A204, SK-ES-1, A673)
Concentration: 0.5, 1, 2 μM
Incubation Time: 24, 48, 72 h
Result: Significantly affected MG-63, RD, and SK-ES-1 viability in 0.5 μM, while all CSCs were sensitive at 1 and 2 μM.

Apoptosis Analysis[1]

Cell Line: Cancer stem cells (HOS, MG-63, RD, A204, SK-ES-1, A673)
Concentration: 0.5, 1, 2 μM
Incubation Time: 48 h
Result: Significantly induced apoptosis of all CSC cultures, with the exception of A204 CSCs.
Generated an increase of the presence of apoptotic cells with concentrated dense granular fluorescence compared to untreated cells, especially at 1 and 2 μM.

Western Blot Analysis[1]

Cell Line: MG-63 cancer stem cells
Concentration: 0.5, 2 μM
Incubation Time: 24 h
Result: Caused a dose-dependent increase of acetyl-histone H3.
Molecular Weight

387.43

Formula

C23H21N3O3
CAS No.
SMILES

O=C(NO)/C=C/C1=NC=C(C=C1)NC(C(C2=CC=CC=C2)CC3=CC=CC=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MC2625 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MC26251776116-75-6MC 2625MC-2625HDACApoptosisHistone deacetylasesPyridinehistone deacetylaseHDAC3HDAC6HDAC1HDAC2HDAC4HDAC5HDAC7HDAC8HDAC9HDAC10HDAC11acetyl-H3acetyl-tubulinCSCs,Inhibitorinhibitorinhibit

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