2. Academic Validation
  3. A novel anti-HIV macrocyclic peptide from Palicourea condensata

A novel anti-HIV macrocyclic peptide from Palicourea condensata

  • J Nat Prod. 2001 Feb;64(2):249-50. doi: 10.1021/np000372l.
H R Bokesch 1,  L K Pannell,  P K Cochran,  R C Sowder 2nd,  T C McKee,  M R Boyd
Affiliations

Affiliation

  • 1 Laboratory of Drug Discovery Research and Development, Division of Basic Sciences, NCI-Frederick, Frederick, Maryland 21702-1201, USA.
PMID: 11430013 DOI: 10.1021/np000372l
Abstract

A 37 amino acid cyclic polypeptide has been isolated from the organic extract of the tropical tree Palicourea condensata. Palicourein (1) is the largest of a growing family of plant Peptides that contain a cyclized amino acid backbone cross-linked via three internal disulfide bridges. Palicourein inhibits the in vitro cytopathic effects of HIV-1RF Infection of CEM-SS cells with an EC50 value of 0.1 microM and an IC50 value of 1.5 microM.

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