2. Academic Validation
  3. Daphnicyclidins A-H, novel hexa- or pentacyclic alkaloids from two species of Daphniphyllum

Daphnicyclidins A-H, novel hexa- or pentacyclic alkaloids from two species of Daphniphyllum

  • J Am Chem Soc. 2001 Nov 21;123(46):11402-8. doi: 10.1021/ja016955e.
J I Kobayashi 1,  Y Inaba,  M Shiro,  N Yoshida,  H Morita
Affiliations

Affiliation

  • 1 Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan. [email protected]
PMID: 11707117 DOI: 10.1021/ja016955e
Abstract

Eight highly modified Daphniphyllum Alkaloids with unprecedented fused hexa- or pentacyclic skeletons, daphnicyclidins A-H (1-8), have been isolated from the stems of Daphniphyllum humile and D.teijsmanni, and their structures were elucidated on the basis of spectroscopic data and chemical means. The stereochemistry was elucidated by combination of NOESY correlations, X-ray crystallographic data, and CD analyses.

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