2. Academic Validation
  3. 10-Shogaol, an antioxidant from Zingiber officinale for skin cell proliferation and migration enhancer

10-Shogaol, an antioxidant from Zingiber officinale for skin cell proliferation and migration enhancer

  • Int J Mol Sci. 2012;13(2):1762-1777. doi: 10.3390/ijms13021762.
Chung-Yi Chen 1,  Kuo-Chen Cheng 2 3 4,  Andy Y Chang 5 6,  Ying-Ting Lin 7,  You-Cheng Hseu 8,  Hui-Min Wang 6
Affiliations

Affiliations

  • 1 Department of Medical Laboratory Science and Biotechnology, School of Medical and Health Sciences, Fooyin University, 151, Ching-Hsueh Road, Ta-Liao District, Kaohsiung 83102, Taiwan.
  • 2 Department of Internal Medicine, Chi-Mei Medical Centre, Tainan 710, Taiwan.
  • 3 Department of Safety Health and Environment, Chung Hwa University of Medical Technology, Tainan 717, Taiwan.
  • 4 Department of Medicine, National Defense Medical Center, Taipei 114, Taiwan.
  • 5 Department of Biology, University of California, Riverside, Riverside, CA 92521, USA.
  • 6 Department of Fragrance and Cosmetic Science, Kaohsiung Medical University, 100, Shih-Chuan 1st Road, San-Ming District, Kaohsiung 80708, Taiwan.
  • 7 Department of Biotechnology, College of Life Sciences, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
  • 8 Department of Cosmeceutics, College of Pharmacy, China Medical University, Taichung 404, Taiwan.
PMID: 22408422 DOI: 10.3390/ijms13021762
Abstract

In this work, one of Zingiber officinale components, 10-shogaol, was tested with 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, metal chelating ability, and reducing power to show antioxidant activity. 10-Shogaol promoted human normal epidermal keratinocytes and dermal fibroblasts cell growths. 10-Shogaol enhanced growth factor production in Transforming Growth Factor-β (TGF-β), platelet derived growth factor-αβ (PDGF-αβ) and vascular endothelial growth factors (VEGF) of both cells. In the in vitro wound healing assay for 12 or 24 h, with 10-shogaol, the fibroblasts and keratinocytes migrated more rapidly than the vehicle control group. Thus, this study substantiates the target compound, 10-shogaol, as an antioxidant for human skin cell growth and a migration enhancer with potential to be a novel wound repair agent.

Keywords

10-shogaol; antioxidant activities; ginger; growth factors; migration; proliferation; skin cell.

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