2. Academic Validation
  3. Cucurbitane-type triterpenoids from the stems and leaves of Momordica charantia

Cucurbitane-type triterpenoids from the stems and leaves of Momordica charantia

  • Fitoterapia. 2014 Jun;95:75-82. doi: 10.1016/j.fitote.2014.03.005.
Gao-Ting Zhao 1,  Jie-Qing Liu 2,  Yuan-Yuan Deng 3,  Hai-Zhou Li 1,  Jian-Chao Chen 2,  Zhi-Run Zhang 2,  Lin Zhou 2,  Ming-Hua Qiu 4
Affiliations

Affiliations

  • 1 Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, Yunnan, People's Republic of China.
  • 2 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China.
  • 3 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China; University of Chinese Academy of Science, Beijing 100049, People's Republic of China.
  • 4 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China; University of Chinese Academy of Science, Beijing 100049, People's Republic of China. Electronic address: [email protected].
PMID: 24631764 DOI: 10.1016/j.fitote.2014.03.005
Abstract

Six new cucurbitane-type triterpenoids, karavilagenin F (1), karavilosides XII and XIII (2, 3), momordicines VI, VII, and VIII (4, 5 and 6), along with four known ones, 5β,19-epoxy-25-methoxycucurbita-6,23-diene-3β,19-diol (7), 5β,19-epoxycucurbita-6, 23-diene-3β,19,25-triol (8), kuguacin R (9), and (19R,23E)-5β,19-epoxy-19-methoxycucurbita-6,23,25-trien-3β-ol (10), were isolated from the stems and leaves of Momordica charantia L. Their chemical structures were elucidated by extensive 1D NMR and 2D NMR (HSQC, HMBC, COSY, and ROESY), MS experiments, and CD spectrum. Compound 6 showed weak cytotoxicity against five human Cancer cells lines with IC50 values of 14.3-20.5μmol/L.

Keywords

Cucurbitaceae; Cucurbitane-type triterpenoids; Cytotoxicity; Momordica charantia.

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