2. Academic Validation
  3. The Chinese herb-derived Sparstolonin B suppresses HIV-1 transcription

The Chinese herb-derived Sparstolonin B suppresses HIV-1 transcription

  • Virol J. 2015 Jul 25;12:108. doi: 10.1186/s12985-015-0339-8.
Xin Deng 1,  Yaping Zhang 2,  Feng Jiang 3,  Ran Chen 4,  Peichun Peng 5,  Bin Wen 6,  Jian Liang 7
Affiliations

Affiliations

  • 1 Department of Infectious Diseases, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, 10 Huadong Road, 530011, Nanning, Guangxi Province, China. [email protected].
  • 2 Department of Infectious Diseases, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, 10 Huadong Road, 530011, Nanning, Guangxi Province, China. [email protected].
  • 3 Department of Infectious Diseases, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, 10 Huadong Road, 530011, Nanning, Guangxi Province, China. [email protected].
  • 4 Department of Infectious Diseases, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, 10 Huadong Road, 530011, Nanning, Guangxi Province, China. [email protected].
  • 5 Department of Infectious Diseases, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, 10 Huadong Road, 530011, Nanning, Guangxi Province, China. [email protected].
  • 6 Department of Infectious Diseases, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, 10 Huadong Road, 530011, Nanning, Guangxi Province, China. [email protected].
  • 7 Department of Infectious Diseases, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, 10 Huadong Road, 530011, Nanning, Guangxi Province, China. [email protected].
PMID: 26206295 DOI: 10.1186/s12985-015-0339-8
Abstract

Background: The Chines herb derived Sparstolonin B, (SsnB), is a recently identified natural compound that selectively blocks TLR2- and TLR4-mediated inflammatory signaling. But it is unknown whether this compound has any effect on HIV Infection.

Findings: We found that SsnB treatment blocked HIV-1 transcription via a novel mechanism that requires the TAR region. Treatment of human T cell lines or peripheral blood mononuclear cells with SsnB at 1 μM significantly inhibited HIV production. Lastly, SsnB was able to inhibit HIV in synergy with AZT.

Conclusions: These data suggest that SsnB is a novel natural compound that inhibits HIV-1 transcription and may be a new drug in the treatment of HIV Infection.

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