2. Academic Validation
  3. Oxazolone-Induced Colitis as a Model of Th2 Immune Responses in the Intestinal Mucosa

Oxazolone-Induced Colitis as a Model of Th2 Immune Responses in the Intestinal Mucosa

  • Methods Mol Biol. 2016;1422:253-61. doi: 10.1007/978-1-4939-3603-8_23.
Benno Weigmann 1,  Markus F Neurath 2
Affiliations

Affiliations

  • 1 Department of Medicine 1, University of Erlangen-Nuremberg, Campus for Medical Research, Hartmannstr. 14, 91052, Erlangen, Germany. [email protected].
  • 2 Department of Medicine 1, University of Erlangen-Nuremberg, Campus for Medical Research, Hartmannstr. 14, 91052, Erlangen, Germany.
PMID: 27246039 DOI: 10.1007/978-1-4939-3603-8_23
Abstract

Murine models of intestinal inflammation have been widely used in biomedical research. Similarities in anatomy and physiology between such murine models and patients with inflammatory bowel diseases may allow a better understanding of the pathogenesis of Crohn's disease and ulcerative colitis. Additionally, models of intestinal inflammation may be used for the analysis of potentially new therapeutic agents. One key class of models consists of chemically induced inflammation models. Within this group, colitis induced by the haptenizing agent oxazolone is an important model that results in induction of acute or chronic inflammation of the large bowel. Here, we describe the induction and the analysis of this experimental colitis model.

Keywords

Experimental colitis models; Inflammatory bowel disease; Intestinal mucosa; Oxazolone; Ulcerative colitis.

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