2. Academic Validation
  3. Enhanced Cognitive Effects of Demethoxycurcumin, a Natural Derivative of Curcumin on Scopolamine-Induced Memory Impairment in Mice

Enhanced Cognitive Effects of Demethoxycurcumin, a Natural Derivative of Curcumin on Scopolamine-Induced Memory Impairment in Mice

  • Molecules. 2016 Aug 5;21(8):1022. doi: 10.3390/molecules21081022.
Dong Wook Lim 1,  Hyun Jung Son 2,  Min Young Um 3 4,  In-Ho Kim 5,  Daeseok Han 6,  Suengmok Cho 7,  Chang-Ho Lee 8
Affiliations

Affiliations

  • 1 Research Group of Innovative Special Food, Korea Food Research Institute, Seongnam 13539, Korea. [email protected].
  • 2 Research Group of Innovative Special Food, Korea Food Research Institute, Seongnam 13539, Korea. [email protected].
  • 3 Research Group of Innovative Special Food, Korea Food Research Institute, Seongnam 13539, Korea. [email protected].
  • 4 Division of Food Biotechnology, University of Science & Technology, Daejeon 34113, Korea. [email protected].
  • 5 Research Group of Innovative Special Food, Korea Food Research Institute, Seongnam 13539, Korea. [email protected].
  • 6 Research Group of Innovative Special Food, Korea Food Research Institute, Seongnam 13539, Korea. [email protected].
  • 7 Research Group of Innovative Special Food, Korea Food Research Institute, Seongnam 13539, Korea. [email protected].
  • 8 Research Group of Innovative Special Food, Korea Food Research Institute, Seongnam 13539, Korea. [email protected].
PMID: 27527139 DOI: 10.3390/molecules21081022
Abstract

In the present study, we examined the ameliorating effects of demethoxycurcumin (DMC) on memory impairment induced by scopolamine using passive avoidance and Morris water maze tests in mice. Moreover, to determine the neurobiological effects underlying the ameliorating effects of the DMC, choline acetyltransferase (ChAT) immunoreactivity was evaluated in mice exposed to scopolamine. Our results demonstrated that chronic oral administration (28 days) of DMC (10 mg/kg) improved scopolamine-induced learning impairment in the passive avoidance task and memory impairment in the Morris water maze. Moreover, Choline acetyltransferase (ChAT) activity in the DMC-treated group was significantly increased to 33.03% compared with the control group. Our present finding suggests that DMC ameliorates memory impairments induced by scopolamine treatment through reversing the reduction of hippocampal ChAT expression in mice.

Keywords

Morris water maze; acetyltransferase; demethoxycurcumin; passive avoidance task; scopolamine.

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