2. Academic Validation
  3. Cucurbitane Glucosides from the Crude Extract of Siraitia grosvenorii with Moderate Effects on PGC-1α Promoter Activity

Cucurbitane Glucosides from the Crude Extract of Siraitia grosvenorii with Moderate Effects on PGC-1α Promoter Activity

  • J Nat Prod. 2017 May 26;80(5):1428-1435. doi: 10.1021/acs.jnatprod.6b01086.
Biao Niu 1 2 3,  Chang-Qiang Ke 1,  Bo-Han Li 3 4,  Yuanyuan Li 5,  Yongji Yi 5,  Yongwei Luo 5,  Lin Shuai 3 4,  Sheng Yao 1,  Li-Gen Lin 6,  Jia Li 3 4,  Yang Ye 1 2 3
Affiliations

Affiliations

  • 1 State Key Laboratory of Drug Research and Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zu-Chong-Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China.
  • 2 School of Life Science and Technology, ShanghaiTech University , Shanghai 201210, People's Republic of China.
  • 3 University of Chinese Academy of Sciences , No. 19A Yuquan Road, Beijing 100049, People's Republic of China.
  • 4 Chinese National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 189 Guoshoujing Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China.
  • 5 Guilin Layn Natural Ingredients Corp , Guilin 541199, People's Republic of China.
  • 6 State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau , Avenida da Universidade, Taipa, Macao 999078, People's Republic of China.
PMID: 28448136 DOI: 10.1021/acs.jnatprod.6b01086
Abstract

Seven new cucurbitane glucosides, 11-oxomogrosides III E and IV (1 and 2), 11-oxoisomogroside V (3), 7-oxomogrosides III E and IV (4 and 5), and mogrosides VI A and VI B (6 and 7), were separated from the crude extract of Siraitia grosvenorii. The new structures were defined by analysis of their 1H and 13C NMR, 2D NMR, and HRESIMS data. Especially, the band-selective constant time HSQC and band-selective constant time HMBC techniques were recuited to elucidate the structures of the complex glucoside moieties. Using the PGC-1α promoter driven luciferase reporter assay, the isolated compounds were examined for PGC-1α promoter activity.

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