2. Academic Validation
  3. New neo-clerodane diterpenoids with neurotrophic activity from the aerial parts of Salvia tiliifolia

New neo-clerodane diterpenoids with neurotrophic activity from the aerial parts of Salvia tiliifolia

  • Fitoterapia. 2017 Nov;123:44-50. doi: 10.1016/j.fitote.2017.09.013.
Min Fan 1,  Ying Bao 1,  Zhi-Jun Zhang 2,  Hong-Bin Zhang 3,  Qin-Shi Zhao 4
Affiliations

Affiliations

  • 1 Key Laboratory of Medicinal Chemistry for Natural Resources (Yunnan University), Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China.
  • 2 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China.
  • 3 Key Laboratory of Medicinal Chemistry for Natural Resources (Yunnan University), Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China. Electronic address: [email protected].
  • 4 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China. Electronic address: [email protected].
PMID: 28943287 DOI: 10.1016/j.fitote.2017.09.013
Abstract

Five new neo-clerodane Diterpenoids, tiliifolins A-E (1-5), along with ten known ones, were isolated from the aerial part of Salvia tiliifolia. Their structures were proposed based on 1D and 2D NMR spectroscopic data analysis. All new compounds were evaluated for their neurotrophic activity on PC12 cells and cytotoxicity against five human Cancer cell lines (HL-60, A-549, SMMC-7721, MCF-7, and SW480), and compound 5 showed statistically significant neuroprotective effect in vitro assay.

Keywords

Cytotoxicity; Neo-clerodane diterpenoids; Neurotrophic activities; Salvia tiliifolia.

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