Selective inhibition of leukemia-associated SHP2E69K mutant by the allosteric SHP2 inhibitor SHP099

Affiliations

• 1 Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
• 2 Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
• 3 Department of Drug Discovery, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
• 4 Department of Chemistry, University of South Florida, Tampa, FL, USA.
• 5 Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. [email protected].
• 6 Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA. [email protected].
• 7 Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. [email protected].