2. Academic Validation
  3. Application of Gellan Gum-Based Scaffold for Regenerative Medicine

Application of Gellan Gum-Based Scaffold for Regenerative Medicine

  • Adv Exp Med Biol. 2020;1249:15-37. doi: 10.1007/978-981-15-3258-0_2.
Joo Hee Choi 1,  Wonchan Lee 1,  Cheolui Song 1,  Byung Kwan Moon 2,  Sun-Jung Yoon 3,  Nuno M Neves 4 5 6,  Rui L Reis 4 5 6,  Gilson Khang 7
Affiliations

Affiliations

  • 1 Department of BIN Convergence Technology, Department of Polymer Nano Science & Technology and Polymer BIN Research Center, Jeonbuk National University, Jeonju, South Korea.
  • 2 Department of Polymer Nano Science & Technology, Jeonbuk National University, Jeonju-si, Jeollabuk-do, Republic of Korea.
  • 3 Department of Orthopedic Surgery, Medical School, Jeonbuk National University, Jeonju-si, Republic of Korea.
  • 4 3B's Research Group - Biomaterials, Biodegradables and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of Minho, Guimarães, Portugal.
  • 5 ICVS/3B's - PT Government Associated Laboratory, Braga/Guimarães, Portugal.
  • 6 The Discoveries Centre for Regenerative and Precision Medicine, Headquarters at University of Minho, Guimarães, Portugal.
  • 7 Department of BIN Convergence Technology, Department of Polymer Nano Science & Technology and Polymer BIN Research Center, Jeonbuk National University, Jeonju, South Korea. [email protected].
PMID: 32602088 DOI: 10.1007/978-981-15-3258-0_2
Abstract

Gellan gum (GG) is a linear microbial exopolysaccharide which is derived naturally by the fermentation process of Pseudomonas elodea. Application of GG in tissue engineering and regeneration medicine (TERM) is already over 10 years and has shown great potential. Although this biomaterial has many advantages such as biocompatibility, biodegradability, nontoxic in nature, and physical stability in the presence of cations, a variety of modification methods have been suggested due to some disadvantages such as mechanical properties, high gelation temperature, and lack of attachment sites. In this review, the application of GG-based scaffold for tissue engineering and approaches to improve GG properties are discussed. Furthermore, a recent trend and future perspective of GG-based scaffold are highlighted.

Keywords

Application; Gellan gum; Nature derived; Regeneration; Scaffold; Tissue engineering.

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