2. Academic Validation
  3. Hydroxysafflor yellow A promotes multiterritory perforating flap survival: an experimental study

Hydroxysafflor yellow A promotes multiterritory perforating flap survival: an experimental study

  • Am J Transl Res. 2020 Aug 15;12(8):4781-4794.
Chenxi Zhang 1 2 3,  Zhenxuan Shao 1 2 3,  Zhentai Chen 1 2 3,  Chen Lin 1 2 3,  Sunli Hu 1 2 3,  Zhiling Lou 1 2 3,  Jiafeng Li 1 2 3,  Xuanqi Zheng 1 2 3,  Nan Lin 1 2 3,  Weiyang Gao 1 2
Affiliations

Affiliations

  • 1 Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou 325000, Zhejiang, P. R. China.
  • 2 Zhejiang Provincial Key Laboratory of Orthopaedics Wenzhou 325000, Zhejiang, P. R. China.
  • 3 The Second Clinical Medical College of Wenzhou Medical University Wenzhou 325027, P. R. China.
PMID: 32913550
Abstract

The use of perforator flaps is a common surgical technique in wound repair. However, the area surrounding the multiterritory perforating FLAP often becomes necrotic due to ischemia. Hydroxysafflor yellow A (HSYA), a traditional Chinese medicine extracted from edible safflower, can be used medicinally to promote angiogenesis, inhibit Apoptosis, and alleviate oxidative stress and other biological activities. Here, we investigated the effect of HSYA on perforator FLAP survival and its potential mechanism. Our results demonstrate that HSYA significantly improves the survival area of perforator flaps, increases blood supply, reduces tissue edema, and increases mean vascular density. HSYA treatment promotes angiogenesis and inhibits oxidative stress, Apoptosis, and Autophagy in perforator flaps, suggesting many potential mechanisms for FLAP survival.

Keywords

Hydroxysafflor yellow A; angiogenesis; apoptosis; autophagy; multiterritory perforator flaps; oxidative stress.

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