2. Academic Validation
  3. Effects of cyhalofop-butyl on the developmental toxicity and immunotoxicity in zebrafish (Danio rerio)

Effects of cyhalofop-butyl on the developmental toxicity and immunotoxicity in zebrafish (Danio rerio)

  • Chemosphere. 2021 Jan;263:127849. doi: 10.1016/j.chemosphere.2020.127849.
Bo Cheng 1,  Lufang Zou 2,  Hua Zhang 2,  Zigang Cao 2,  Xinjun Liao 2,  Tianzhu Shen 2,  Guanghua Xiong 2,  Juhua Xiao 3,  Huasheng Liu 2,  Huiqiang Lu 4
Affiliations

Affiliations

  • 1 Jiangxi Engineering Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases, Jiangxi Key Laboratory of Developmental Biology of Organs, Affiliated Hospital of Jinggangshan University, China; Center for Drug Screening and Research, School of Geography and Environmental Engineering, Gannan Normal University, Ganzhou, 341000, Jiangxi, China.
  • 2 Jiangxi Engineering Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases, Jiangxi Key Laboratory of Developmental Biology of Organs, Affiliated Hospital of Jinggangshan University, China.
  • 3 Department of Ultrasound, Jiangxi Provincial Maternal and Child Health Hospital, Nanchang, 330006, China.
  • 4 Jiangxi Engineering Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases, Jiangxi Key Laboratory of Developmental Biology of Organs, Affiliated Hospital of Jinggangshan University, China. Electronic address: [email protected].
PMID: 33297003 DOI: 10.1016/j.chemosphere.2020.127849
Abstract

Cyhalofop-butyl is a kind of aromatic phenoxypropionic acid herbicide widely used in agriculture. However, studies on its immunotoxicity to aquatic organisms have not been reported. In this study paper, morphological, immunological, cytological, biochemical and Molecular Biology methods were used to study the effects of cyhalofop-butyl on the developmental toxicity and immunotoxicity in zebrafish. After cyhalofop-butyl exposed, the results showed that the zebrafish embryos had shorter length, yolk sac edema, significantly reduced number of immune cells, inflammatory response and immunocytes Apoptosis. In addition, we found that the expression of immune-related genes and pro-apoptotic genes were up-regulated, and the JAK-STAT signaling pathway mediated the immunotoxicity induced by cyhalofop-butyl. Therefore, our results indicate that cyhalofop-butyl has developmental toxicity and immunotoxicity to zebrafish, and this study offer new contents for the effects of cyhalofop-butyl exposure on aquatic organisms.

Keywords

Cyhalofop-butyl; Immunotoxicity; JAK-STAT signaling Pathway; Zebrafish.

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