2. Academic Validation
  3. Malformin C, an algicidal peptide from marine fungus Aspergillus species

Malformin C, an algicidal peptide from marine fungus Aspergillus species

  • Ecotoxicology. 2021 Jul;30(5):996-1003. doi: 10.1007/s10646-021-02389-3.
Xiaofan Li 1,  Zhenyao Xia 1,  Bing Wang 2,  Liwen Lai 1,  Jue Wang 2,  Linhai Jiang 3,  Tuchan Li 1,  Jiahui Wu 1,  Liyan Wang 4
Affiliations

Affiliations

  • 1 Guangdong Provincial Key Laboratory for Plant Epigenetics, Shenzhen Key Laboratory of Marine Bioresource and Eco-environmental Science, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, 518071, PR China.
  • 2 Shenzhen Institute for drug control, Shenzhen Key Laboratory of Drug Quality Standard Research, Shenzhen, 518057, PR China.
  • 3 Instumental Analysis Center of Shenzhen University, Shenzhen, 518071, PR China.
  • 4 Guangdong Provincial Key Laboratory for Plant Epigenetics, Shenzhen Key Laboratory of Marine Bioresource and Eco-environmental Science, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, 518071, PR China. [email protected].
PMID: 33755843 DOI: 10.1007/s10646-021-02389-3
Abstract

A natural compound with the algicidal effect was isolated from the culture medium of Aspergillus sp. SCSIOW2 and was identified as malformin C, which was based on the data of 1H-NMR, 13C-NMR, and ESI-MS. Malformin C exhibited dose-dependent algicidal activities against two strains of noxious red tide algae, Akashiwo sanguinea and Chattonella marina. The activity against A. sanguinea was stronger than that against C. marina (the algicidal activity of 58 and 36% at 50 μM treatment for 2 h, respectively). Morphology changes including perforation, plasmolysis, and fragmentation of algal cells were observed. Malformin C induced a significant increase in ROS level, caused the damage of SOD activity, and led to the massive generation of MDA contents in algae cells. To our knowledge, this is the first report of the cyclic peptide described as an algicidal compound against HABs.

Keywords

Akashiwo sanguinea; Algicidal; Aspergillus; Chattonella marina; Malformin C.

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